摘要
目的：测定肺癌患者血清细胞角蛋白19片段（CYFRA21-1）及癌胚抗原（CEA）浓度，探讨其临床应用价值。方法：对46例确诊肺癌患者和30例肺良性疾病患者测定血清CYFRA21－1及CEA水平，并进行分析。结果：（1）肺癌患者血清CYFRA21－1及CEA水平显著高于肺良性疾病患者（P＜0.001）。（2）CYFRA21－1检测鳞癌的敏感性为77％，而CEA在腺癌的敏感性为70％，鳞癌与腺癌的CYFRA21－1及CEA的浓度差异有显著性（P＜0.001）。结论：CYFRA21－1对鳞癌具有较高的阳性诊断率，而CEA较适用于腺癌，二者联合检测可提高诊断的准确性。
Objective: To detect the concentrations of CYFRA21- 1 and CEA in serum of lung cancer patient and to probe their clinical value. Methods: The conccntrations of CYFRA21 - 1 and CEA in serum of 46cases of lung cancer patient and 30 cases of benign lung disease were detected and analysed. Results: There weresignificant differences of CYFRA21 - 1 and CEA conccntrations in serum between the patient with lung cancerand with benign lung disease(P < 0. 001 ). The CYFRA21- 1 sensitivity for examining squamous cancer was77% and the CEA sensitivity for examining adenocarcinoma was 70% , there were significant differences ofCYFRA21 - 1 and CEA concentraTion between squamous cancer and adenocarcinoma (P < 0. 001 ). Conclusions: CYFRA21 - 1 had a high positive diagnostic rat on squamous cancer, while CEA is more applicable to adenocarcinoma, and combining with both CYFRA21 - 1 and CEA could improve the accuracy of diagnosis.
出处
《齐齐哈尔医学院学报》
1999年第3期202-203,共2页
Journal of Qiqihar Medical University
