摘要
目的 探讨与广西鼻咽癌高发有关的非病毒危险因素 ,为鼻咽癌病因学及其防治研究提供科学依据。方法 选择 2 0 0 0年 3月至 2 0 0 1年 5月期间在广西南宁市两家省级医院住院治疗 ,经病理学确诊的鼻咽癌病人 175例 ,以及与病例相匹配的 35 0名对照病人 ,采用 1∶2病例 -对照研究方法 ,调查居住、职业、饮食、疾病等方面的情况 ,先使用单因素条件logistic回归模型对资料进行分析 ,将有意义的因素进行多因素条件logistic回归分析 ,得出与鼻咽癌发病有关的因素。 结果 通过多因素条件logistic回归分析 ,筛选出 7个与鼻咽癌发生有关的因素。结果表明 ,文化程度越低 ,职业接触有害物质 ,住房东西朝向 ,使用煤或柴草做燃料 ,每天吸烟越多 ,常吃腌制食品 ,有鼻咽癌家族史等 ,能增加鼻咽癌发生的危险性 ,其OR值分别为 :0 713,1 832 ,2 191,3 6 77,1 16 4 ,3 12 0 ,15 5 6 9。结论 广西鼻咽癌高发除与遗传因素有关外 ,职业、环境因素和生活饮食习惯在鼻咽癌的发生中也起一定的作用。
Objective To investigate non viral risk factors associated with the high incidence of nasopharyngeal carcinoma(NPC)in Guangxi,and to provide scientific basis for etiology,prevention and treatment of NPC.Methods A 1∶2 matched hospital based case control study with 175 NPC pathologically diagnosed cases and 350 controls was carried out from March 2000 to May 2001 in two Nanning provincial hospitals.Their residence,occupation,dietary and medical history were investigated.Mono factor and multi factor conditional logistic regression model was used to select NPC related risk factors.Results Multi factor conditional logistic regression model analysis revealed that low education level,occupational exposure to hazardous agents,living in the room facing east or west,using coal or firewood as fuels,increased cigarettes smoking,eating salt preserved food frequently and NPC family history could increase the risk of NPC.The OR value for each risk factor was 0 713,1 832,2 191,3 677,1 164,3 120 and 15 569 respectively.Conclusions Besides genetic factor,occupation,environment and life style could also play roles in the high incidence of NPC in Guangxi.
出处
《工业卫生与职业病》
CAS
CSCD
北大核心
2002年第4期193-196,共4页
Industrial Health and Occupational Diseases
