摘要
目的 探讨超声光散射成像技术（US-DOT）用于评估乳腺癌新辅助化疗（NCT）效果的可行性.方法 乳腺癌NCT病例50例,按照化疗后的临床疗效评价标准分为完全缓解（CR）组、部分缓解（PR）组、稳定（SD）组、进展（PD）组.对于50例乳腺原发病灶进行化疗前后的US-DOT检查,检测肿瘤血红蛋白总量（HbT）值.用方差分析比较各组治疗前后HbT的差异;用Pearson相关分析HbT相对变化量与肿瘤直径变化的关系;用混合效应模型评估HbT值和肿瘤直径的关系.结果 NCT结束后,50例患者中CR组8例,PR组30例,SD组12例,PD组0例.化疗前后肿瘤直径和HbT在CR组与PR组差异均有统计学意义（P ＜0.001）,而在SD组两者差异均无统计学意义（P＞0.05）.化疗后CR组HbT相对变化比的平均值为-0.525±0.222,PR组为-0.328±0.180,SD组为-0.173±0.167,组间比较差异具有统计学意义（P＜0.05）.Pearson相关分析显示NCT结束后肿瘤HbT值下降,其直径亦下降,肿瘤HbT相对变化比与直径的变化具有相关性（r=0.6）.混合效应模型也表明肿瘤HbT与直径的变化相关且趋势一致.结论 US-DOT参数HbT与肿瘤直径密切相关,可用于评估乳腺癌新辅助化疗的疗效.
Objective To investigate the value of ultrasound-diffuse optical tomography（US-DOT） in evaluation of the response to neoadjuvant chemotherapy （NCT） in patients with breast cancer.Methods Fifty women with breast cancer confirmed by biopsy-pathology scheduled to undergo NCT were enrolled.US-DOT was performed and the total hemoglobin concentration（HbT） prior to and at the end of NCT.According to the response to treatment in solid tumors,patients were divided into complete response（CR） group,partial response （PR） group,stable disease （SD） group and progressive disease （PD） group.The analysis of variance compared the differences of HbT before and after NCT in each group; Pearson correlation analyzed the relationship between the relative HbT variation and the tumor size changes;Mixedeffects model analyzed the relationship between HbT and tumor size.Results After NCT,CR group had 8 cases,PR group 30 cases,SD group 12 cases and no PD cases.Before and after NCT,the mean relative variations of HbT before and after NCT were-0.525 ± 0.222,-0.328 ± 0.180 and-0.173 ± 0.167 in CR,PR and SD groups,respectively.The differences of HbT before and after NCT were statistically significant in each group （P ＜0.05）.There was significant difference among tumor diameter and HbT in CR group and PR group （P ＜0.001）;while in the SD group,there was no difference among tumor diameter and HbT （P ＞ 0.05）.The change of HbT after NCT showed positive correlation with the change in tumor size （r =0.6）.Mixed-effects model also showed that HbT change was associated with tumor size.Conclusions USDOT marker HbT is closely related to tumor size of breast cancer before and after NCT and may be applied to evaluate the response of breast cancer to NCT.
出处
《中华超声影像学杂志》
CSCD
北大核心
2014年第12期1065-1069,共5页
Chinese Journal of Ultrasonography
基金
上海市卫生和计划生育委员会科研课题面上项目（201440395）
金山区科学技术创新基金项目（2014-3-01）
复旦大学附属肿瘤医院影像基金（YX201301YJ）
关键词
超声检查
乳腺肿瘤
化学疗法
辅助
超声光散射
Ultrasonography
Breast neoplasms
Chemotherapy, adjuvant
US-diffuse optical tomography
