摘要
目的探讨50岁以下短暂性脑缺血发作（TIA）患者单纯舒张期高血压（IDH）与颈动脉溃疡斑块（CAPU）的相关性。方法选取132例50岁以下TIA患者,根据颈动脉彩超检查结果分为颈动脉溃疡斑块组（CAPU组,n=70）和非溃疡斑块组（非CAPU组,n=62）。检测患者血压情况,利用Logistic回归模型,分析患者临床资料及IDH与CAPU的相关性。结果 CAPU组高血压病、饮酒史比率、空腹血糖、糖化血红蛋白水平及舒张期血压水平显著高于非CAPU组（P〈0.05~0.001）,IDH患者的比例（58.57%）也显著高于非CAPU组（40.32%）（P=0.0364）。CAPU组IDH者与神经系统局灶症状对侧CAPU的检出率（85.37%）明显高于非IDH的患者（75.86%）（P=0.0224）。多因素分析结果显示,IDH是CAPU形成的独立危险因素（OR=1.052,95%CI：1.137~3.254,P=0.013）。结论 IDH可能导致50岁以下TIA患者CAPU的形成。
Objective To investigate the association of isolated diastolic hypertension（IDH） with carotid artery plaque ulceration（CAPU） in transient ischemie attack（TIA） patients under the age of 50. Methods One hundred and thirty-two patients diagnosed with TIA were enrolled in this study, whose age was below 50 years old. They were divided into two groups according to the findings of carotid ultrasonography ： CAPU group （ n = 70 ） and non-CAPU group （n = 62 ）. IDH was measured, clinical data and the association of IDH with CAPU were evaluated by the Logistic regression model. Results The rate of hypertension, drinking history, fasting blood glucose, hemoglobin A1C and diastolic blood pressure level of CAPU group were significantly higher than those of non-CAPU group （P 〈 0. 05 - 0. 001 ）. Compared with the non-IDH patients, The rate of IDH patients in CAPU group （58.57%） was significantly higher than in non-CAPU group （40.32%）（P = O. 0364 ）. The detection rate of neurological deficit eontralateral CAPU was significantly higher in IDH patients in CAPU group（ 85.37% ） than in non-IDH patients in CAPU group （75.86%） （P = 0. 0224）. The multivariate analysis showed that iDH was the independent risk factor of CAPU（ OR = 1. 052, 95% CI： 1. 137 -3. 254,P =0. 013）. Conclusion IDH can lead to the formation of CAPU in TIA patients under the age of 50.
出处
《临床神经病学杂志》
CAS
北大核心
2014年第6期413-415,共3页
Journal of Clinical Neurology
关键词
短暂性脑缺血发作
单纯舒张期高血压
颈动脉溃疡斑块
transient ischemic attack
isolated diastolic hypertension
carotid artery plaque ulceration
