摘要
肝星状细胞（HSC）在肝纤维化中的作用已被公认,近年来HSC在肝脏肿瘤微环境中的作用也逐渐引起人们重视.血小板衍生生长因子（PDGF）是HSC最重要的有丝分裂原,其在HSC的活化中具有极为重要的作用.HSC既是PDGF的作用靶细胞,同时也可分泌PDGF,从而形成PDGF激活HSC的双向循环模式.PDGF可通过MAPK、PI-3K、Ca2＋、JAK等信号通路激活HSC.研究PDGF激活HSC在肝脏肿瘤微环境中的作用机制,寻找靶向抑制PDGF及肝星状细胞的相应方法,有望为肝脏肿瘤的治疗提供新的方向.
The function of hepatic stellate cell （HSC）in liver fibrosis has been well recognized.In recent years,the role of HSC in the liver tumor microenvironment have been paid increasing attention.Platelet derived growth factor （PDGF） is the most important mitogen of hepatic stellate cell,and plays an important role in the activation of hepatic stellate cell.Hepatic stellate cell is not only the target cells of PDGF,but also PDGF-secreting cells.Thus a bi-directional cycle mode of PDGF activating hepatic stellate cell has been established.The signaling pathways of HSC activation include MAPK,PI-3K,Ca2＋ and JAK pathways.To explore PDGF activating hepatic stellate cell in liver tumor microenvironment and to find the new methods of targeting PDGF and hepatic stellate cell,may help us find a new direction for the treatment of hepatocellular carcinoma.
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2014年第12期905-909,共5页
Chinese Journal of Hepatobiliary Surgery
基金
国家自然科学基金（30971340）
关键词
肝星状细胞
血小板衍生生长因子
肝癌
肿瘤微环境
Hepatic stellate cell
Platelet derived growth factor
Hepatocellular carcinoma
Tumor microenvironment
