摘要
目的探讨黄体酮联合地屈孕酮治疗先兆流产的临床效果。方法选取本院2012年12月-2014年6月收治的先兆流产患者,随机抽取74例作为研究对象,按随机双盲法将患者分为观察组与对照组。对照组37例采用地屈孕酮治疗,观察组37例在对照组基础上给予黄体酮肌内注射治疗。治疗后,比较两组患者的孕酮水平、保胎成功率、症状缓解及完全消失时间及不良反应发生率。结果观察组患者的孕酮水平与对照组比较,差异无统计学意义（P〉0.05）;观察组的保胎成功率为91.89%,明显高于对照组的72.97%,差异有统计学意义（P〈0.05）;观察组患者的症状缓解及完全消失时间明显短于对照组,差异有统计学意义（P〈0.05）;观察组的不良反应发生率为5.40%（2例）,明显低于对照组的16.22%（6例）,差异有统计学意义（P〈0.05）。结论黄体酮联合地屈孕酮治疗先兆流产的临床效果显著,可缓解症状,不良反应少,值得临床推广应用。
Objective To investigate clinical effect of progesterone combined with dydrogesterone in the treatment of threatened miscarriage. Methods From December 2012 to June 2014,74 patients with threatened miscarriage admitted into our hospital were randomly selected as research objects.By random and double blind method,they were evenly divided into the observation group and control group.In the control group,dydrogesterone was applied for the treatment,while in the observation group,on the basis of the control group,progesterone for intramuscular injection was provided.After therapy,progesterone level,success rate of tocolysis,time of symptom alleviating and disappearing completely, and incidence rate of adverse reaction were compared in both groups. Results There was no statisticsal difference of progesterone level in the two groups（P〉0.05）.The success rate of tocolysis in the observation group（91.89%） was obviously higher than that in the control group（72.97%）,and there was a statistical difference in the two groups（P〈0.05）.In the observation group,time of symptom alleviating and disappearing completely was obviously shorter than that in the control group,and there was a statistical difference in the two groups（P〈0.05）.The incidence rate of adverse reaction in the observation group（5.40%） was obviously lower than that in the control group and there was a statistical difference in the two groups（P〈0.05）. Conclusion The clinical effect of progesterone combined with dydrogesterone in the treatment of threatened miscarriage is remarkable and it can alleviate the symptoms with fewer adverse reaction,which is worthy of expansion and promotion in clinic.
出处
《中国当代医药》
2015年第1期86-88,共3页
China Modern Medicine
关键词
黄体酮
地屈孕酮
先兆流产
Progesterone
Dydrogesterone
Threatened miscarriage
