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脑卒中与同型半胱氨酸、血脂、血糖及纤维蛋白原的相关分析 被引量：9

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摘要 目的:研究脑梗死、脑出血等脑卒中与血清同型半胱氨酸(Hcy)、血脂、纤维蛋白原(FIB)和空腹血糖(FBG)的相关性。方法:检测47例脑梗死,50例脑出血及40例非脑卒中患者入院时血清Hcy、血脂、FIB和FBG的值,比较各组患者指标的差异,同时分析Hcy和其他因素的相关性。结果:脑梗死组及脑出血组血清Hcy、低密度脂蛋白(LDL)-C、FIB和FBS水平高于对照组(P<0.05),但脑梗死组与脑出血组之间比较差异无统计学意义(P>0.05)。非条件Logistic回归分析显示Hcy与脑梗死及脑出血有关(P<0.05),FIB仅与脑出血有关(P<0.05)。血清Hcy的增高和TG、LDL-C、FIB和FBG的增高无相关性(均P>0.05)。结论:脑卒中与血清Hcy、FIB、TG、LDL-C和FBG密切相关,但Hcy的增高和TG、LDL-C、FIB和FBG的增高无相关性(均P>0.05),Hcy可能是脑卒中的重要独立危险因素。
作者 林伟平 向彩霞 黄文
机构地区 广西壮族自治区总工会陆川温泉疗养院神经内科 广西医科大学第一附属医院神经内科
出处 《广西医科大学学报》 CAS 2014年第6期977-979,共3页 Journal of Guangxi Medical University
基金 天士力杯脑血管病科学研究基金资助项目(No.YXZW2013005)
关键词 脑卒中 同型半胱氨酸 血脂 纤维蛋白原 空腹血糖
分类号 R743 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献10

  • 1Zhong C, Lv L, Liu C, et al. High homocysteine and blood pressure related to poor outcome of acute isehe-mia stroke in chinese population[J]. PLoS One,2014, 9(9) :107 498.
  • 2Tseng YL,Chang YY, Liu JS, et al. Association of plas- ma homocysteine concentration with cerebral white matter hyperintensity on magnetic resonance images in stroke patients[J]. J Neurol Sei, 2009,284(1-2) : 36- 39.
  • 3滕晓茗,周微雅,杨霞芳,黄燕,李瑶宣,林慧琼,李吕力.同型半胱氨酸对脑微血管内皮细胞损伤的研究[J].广西医科大学学报,2005,22(5):669-671. 被引量：1
  • 4Swarowska M, Polezak A, Pera J, et al. Hyperfibrino- genemia predicts long-term risk of death after ischemic stroke[J]. J Thromb Thrombolysis, 2014,38 (4) : 517- 521.
  • 5Chitsaz A, Mousavi SA, Yousef Y, eta]. Comparison of changes in serum fibrinogen level in primary in- tracranial hemorrhage (ICH) and isehemic stroke[J]. ARYA Atheroscler, 2012,7 (4) : 142-145.
  • 6孟艳梅,刘庆.高敏C反应蛋白和纤维蛋白原水平与急性脑血管病的相关性研究[J].脑与神经疾病杂志,2011,19(1):66-70.
  • 7Tapia-Perez J H, Gehring S, Zilke R, et al. Effect of in- creased glucose levels on short-term outcome in hyper- tensive spontaneous intracerebral hemorrhage[J]. Clin Neurol Neurosurg, 2014,118 : 37-43.
  • 8Shao B, Bayraktutan U. Hyperglycaemia promotes hu- man brain microvascular endothelial cell apoptosis via induction of protein kinase C-131 and prooxidant enzyme NADPH oxidase[J]. Redox Biol, 2014,28,2 : 694-701.
  • 9Kushner M, Nencini P,Reivich M, et al. Relation hy- perglucemia early in isehemic infarction to cerebra a- natomy, metabolism and clinical outcorne[J]. Ann Neu- ral, 1990,28 : 129-132.
  • 10Carlucci A, Cigliano L, Maresca B, et al. LCAT cho- lesterol esterification is associated with the increase of ApoE/ApoA-I ratio during atherosclerosis progression in rabbit[J]. J Physiol Biochem,2012,68(4) :541-553.

二级参考文献7

  • 1Sacco RL, Roberts JK, Jacobs BS.Homocysteine as a risk factor for ischemic stroke:an epidemiological story in evolution.Neuroepidemiology,1998,17(4):167-173.
  • 2Guthikonda S, Haynes WG. Homocysteine as a novel risk factor foratherosclerosis.Curropin Cardiol,1999,14(4):283-291.
  • 3Lorentz K, Klauke R, Schmidt E.Recommendation for the determination of the catalyticconcentration of lactate dehydrogenase at 37 degrees C. Standardization Committee of theGerman Society for Clinical Chemistry, Enzyme Working Group of the German Society forClinical Chemistry.Eur J Clin Chem Clin Biochem (Germany),1993,31(12):897-899.
  • 4Finkelstein JD. The metabolism of homocysteine: pathways and regulation.Eur JPediatr,1998,157(Suppl 2):S40-S44.
  • 5Haung GS,Wang Z,Wang SC, et al. Intracellular generation of MDA-lYS epitope in foamcells. Life sci,1999,65(3):285-296.
  • 6McDowell I,Lang D. Homocysteine and Endothelial Dysfunction: A Link with CardiovascularDisease. J Nutr,2000,130(2S Suppl):369s.
  • 7张继东,张维东,崔红燕,孟红,刘德山,张冰.高半胱氨酸对血管内皮细胞的损伤作用及中药抗损伤的实验研究[J].山东医科大学学报,2001,39(6):512-513. 被引量：26

同被引文献106

  • 1Lewiugton S, Whitlock G, Clarke R, et al. Blood cholesterol and vascular mortality by age, sex and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet, 2007,370 : 1829-1839.
  • 2Karen L, Furie MD. Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack. Stroke,2011,42:227-276.
  • 3The European Stroke Organisation (ESO)Executive Committee and the ESO Writing Committee. Guidelines for Management of Ischaemic Stroke and Transient Ischaemic Attack Cerebrovascular Diseases ,2008,25.
  • 4Kwon HM, Lee YS, Bae H J, et al. Homocysteine as a predictor of early neurological deterioration in acute ischemic stroke[ J]. Stroke, 2014,45(3) :871 -873.
  • 5Shi Z, Guan Y, Huo YR, et al. Elevated total homocysteine levels in acute ischemic stroke are associated with long - term mortality [ J ]. Stroke,2015,35(3) :456 -459.
  • 6Tang CZ, Zhang YL, Wang WS, et al. Serum levels of high - sensi- tivity C -reactive protein at admission are more strongly associated with poststroke depression in acute ischcmic stroke than homocysteine levels [ J ]. Mol Neurobiol, 2015,32 ( 6 ) : 785 - 789.
  • 7Tu WJ, Zhao SJ, Liu TG, et al. Combination of high - sensitivity C - reactive protein and homocysteine predicts the short - term outcomes of Chinese patients with acute ischemic stroke [ J]. Neurol Res,2013, 35(9) :912 -921.
  • 8Wiseman S, Marlborough F, Doubal F, et al. Blood markers of coag- ulation, fibrinolysis, endothelial dysfunction and inflammation in lacu- nar stroke versus non - lacunar stroke and non - stroke: systematic re- view and meta- analysis[ J]. Cerebrovasc Dis,2014,37( 1 ) :64 -75.
  • 9Zhong C, Lv L, Liu C, et al. High homocysteine and blood pressure related to poor outcome of acute ischemia stroke in Chinese population [J]. PLoS One,2014,9(9) :498 -501.
  • 10王加,张杰,张丽霞.缺血性脑卒中患者血液流变学的改变[J].南京医科大学学报（自然科学版）,2009,29(2):232-234. 被引量：12

引证文献9

二级引证文献51

广西医科大学学报
2014年 第6期

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