摘要
目的:探讨奥氮平联合帕罗西汀治疗难治性抑郁症患者的临床疗效。方法:选取难治性抑郁症患者112例,采用数字随机法分为两组,56例患者采用帕罗西汀治疗为对照组,56例患者采用奥氮平联合帕罗西汀治疗为观察组,疗程8周。采用汉密尔顿焦虑量表(HAMA)评定焦虑状况,采用汉密尔顿抑郁量表(HAMD)评定抑郁状况,采用生活质量综合评定问卷(GQOL-74)评定生活质量。比较两组患者的治疗效果及不良反应情况。结果:治疗后,两组患者HAMA评分、HAMD评分均显著降低,而物质生活评分、心理功能评分、社会功能评分、躯体功能评分、总体生活质量评分均显著增加。观察组患者HAMA评分、HAMD评分均明显低于对照组,观察组患者物质生活评分、心理功能评分、社会功能评分、躯体功能评分、总体生活质量评分、总有效率均明显高于对照组,差异均有统计学意义(P<0.05)。结论:奥氮平联合帕罗西汀是治疗难治性抑郁症患者的有效方法,可明显改善患者的心理状况,显著提高患者的生活质量,临床疗效显著且安全性高,值得临床推广使用。
Objective：To investigate clinical effect of Olanzapine combined with Paroxetine in treatment of refractory depres-sion patient. Methods：112 patients with refractory depression were selected and randomly divided into two groups according to random number table. 56 patients treated with Paroxetine as control group and other 56 patients treated with Olanzapine combined with Paroxe-tine as observation group. Course of treatment was 8 weeks. Anxiety was evaluated by Hamilton anxiety scale （ HAMA） . Depression was evaluated by Hamilton depression scale （HAMD）. Quality of life was evaluated by general quality of life inventory （GQOL-74）. Therapeutic effect and adverse reactions were compared between the two groups. Results： After the treatment, HAMA score and HAMD score decreased significantly while material life score, psychological function score, social function score, physical function score, and overall quality of life score increased significantly in two groups. HAMA score and HAMD score in observation group were significantly lower than those in control group. Material life score, psychological function score, social function score, physical function score, overall quality of life score, and total efficiency in observation group were significantly higher than those in control group. Differ-ences were statistically significant （P〈0. 05）. Conclusions：Olanzapine combined with paroxetine is an effective method in the treat-ment of refractory depression, and can significantly improve psychological status and quality of life. Olanzapine combined with paroxe-tine has a significant clinical effect and a high safety and is worthy of clinical use.
出处
《中国民康医学》
2015年第2期7-9,12,共4页
Medical Journal of Chinese People’s Health
