摘要
目的比较舍曲林和马普替林对抑郁症患者的生活质量的影响。方法将72例抑郁症患者随机分为舍曲林组(36例)和马普替林组(36例),治疗8周,两组均在治疗前后以汉密尔顿抑郁量表(HAM D)、药物副反应量表(TESS)、生活质量综合评定问卷(GQOL I)评定。结果①治疗8周末,舍曲林组和马普替林组HAM D评分均明显下降(P<0.01),两组疗效无显著性差异(t=1.226,P>0.05);②舍曲林副反应少于马普替林(P<0.05);③舍曲林组对生活质量各维度改善明显(P<0.01),马普替林组在躯体功能及社会功能无明显改善(P>0.05),在物质生活、心理功能方面改善明显(P<0.01)。结论舍曲林治疗抑郁症疗效与马普替林无显著差异(P>0.05),但不良反应少,对生活质量的改善优于马普替林。
Objective To compare the life quality of sertraline and maprotiline in the treatment of depression.Methods A total of 72 patients with depression were divided into Sertraline and Maprotiline groups with 36 patients respectively,and were treated for eight weeks.Hamilton Depression Rateing Scale（HAMD）,Treatment Emergent Symptom Scale（TESS）,and General Quality of Life Inventory（GQOLI） were used before and at the end of study.Results ①At the end of 8 weeks,Sertraline group and Maprotiline group were significantly lower in HAMD score（P〈0.01）.No significant difference was found in the curative effects between the two groups（t=1.226,P〉0.05） at the end of 8 weeks.② The side effects in Sertraline group were fewer than those of Maprotiline group.③Sertraline group（P〈0.01） improved significantly the dimensions of quality life;Maprotiline group did not improve physical function and social function（P〉0.05）,but improved significantly the material life and material function（P〈0.01）.Conclusion Sertraline shows no significant differences compared with Maprotiline in treatment of depression（P〉0.05）,but fewer side effects,meanwhile significantly improves quality of life.
出处
《中国健康心理学杂志》
2010年第11期1287-1288,共2页
China Journal of Health Psychology
关键词
抑郁症
舍曲林
马普替林
生活质量
Depressive disorder
Sertraline
Maprotiline
life quality
