摘要
目的:观察阿托伐他汀对糖尿病肾病患者肾功能相关血清指标及肾脏纤维化的影响。方法:选取本院2011年4月至2013年6月收治的80例糖尿病肾病患者为研究对象,将80例糖尿病肾病患者遵循随机分配的原则分为对照组(常规糖尿病肾病治疗组)40例和观察组(常规糖尿病肾病治疗加阿托伐他汀组)40例,然后将两组糖尿病肾病患者治疗前与治疗后6周、12周及24周时的肾功能相关血清指标及肾脏纤维化指标进行分别检测与比较。结果:观察组患者在治疗后6周、12周及24周时的血清β2-MG、hs-CRP、Scr及UA等肾功能相关指标均低于对照组,且Cys C、TIMP-1、TGF-β1及CⅣ等肾纤维化指标也显著地低于对照组,P均<0.05。结论:阿托伐他汀可有效改善糖尿病肾病患者的肾功能及肾脏纤维化,对于上述方面的相关血清指标有较佳的控制作用。
Objective：To observe the influence of atorvastatin for the renal function related serum inde-xes and renal fibrosis of patients with diabetic nephropathy （ DN）.Method：80 patients with diabetic ne-phropathy in our hospital from April 2011 to June 2013 were as the study object ,They were divided into control group （ conventional diabetic nephropathy treatment group ） with 40 cases and observation group （ conven-tional diabetic nephropathy treatment and atorvastatin group ） with 40 cases according to the method of random allocation,then the renal function related serum indexes and renal fibrosis indexes of two groups before the treatment and at 6th,12th and 24th week after the treatment were respectively detected and compared .Re-sult：The renal function related indexes including serum β2-MG,hs-CRP,Scr and UA of observation group at 6th,12th and 24th week after the treatment were all lower than those of control group ,renal fibrosis indexes including CysC ,TIMP-1,TGF-β1 and CⅣwere all significantly lower than those of control group too ,all P〈0.05.Conclusion：The atorvastatin can effectively improve the renal function and renal fibrosis of patients with diabetic nephropathy ,and it has better role for the control of those related serum indexes .
出处
《河北医学》
CAS
2015年第1期49-52,共4页
Hebei Medicine
基金
中国高校医学期刊临床专项资金项目
(编号:112210587)
