摘要
目的:通过对肺部和呼吸道感染疾病风邪犯肺和非风邪犯肺证患者白介素-1β(IL-1β)、白介素-4(IL-4)、白介素-6(IL-6)、白介素-8(IL-8)4项指标的分析,探求外风是否为导致4项指标变化的本质原因。方法:采用前瞻性、多中心、大样本注册登记式研究,分析数据库中204例肺部及呼吸道感染疾病患者的信息,采用倾向性评分的方法,通过对肺部和呼吸道感染疾病风邪犯肺和非风邪犯肺证患者IL-1β、IL-4、IL-6、IL-8 4项血液样本检测指标的分析,探求外风是否为导致4项指标变化的本质原因。结果:控制了混杂因素之后,风邪犯肺较非风邪犯肺对IL-1β、IL-6两项指标的影响具有显著意义(P<0.05)。结论:外风是影响IL-1β、IL-6的本质因素,还需实验室基础研究及大样本前瞻性研究进一步证实。
Objective： To explore whether the wind is the essential cause of the change of the four markers through analyzing four markers such as IL-1β, IL-4, IL-6 and IL-8 of the lung and respiratory infection disease patients with syndrome of wind invading lung and the other syndromes. Methods： This study was a prospective, multicenter, large sample registration type study. The information of 204 patients with lung and respiratory infections diseases in the database was analyzed by using propensity score methods. The study explored whether the wind is the essential cause of the change of the four markers through analyzing four markers of blood sample such as IL-1β, IL-4, IL-6 and IL-8 of the lung and respiratory infection disease patients with syndrome of wind iavading lung and the other syndromes. Results： It showed that there was a statistically significant difference between the wind attacking lung syndrome group and the other group in IL-1β and IL-6 after controlling for confounding factors （P〈0.05）, Conclusion： Wind is the essential cause of the change of IL-1β and IL-6 in lung and respiratory infection disease, basic laboratory research and large sample prospective studies are warranted.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2014年第12期4009-4014,共6页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金青年基金项目(No.81102666)
国家中医药管理局中医药行业科研专项(No.200907001-5-6)~~
