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炎症体研究进展 被引量：6

Research Advances in Inflammasome
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摘要 炎症体(inflammasome)是一种多蛋白复合体,通过激活半胱天冬酶-1(caspase-1)调控白细胞介素-1β(IL-1β)和IL-18的加工和成熟,进而参与机体的免疫反应。炎症体作为炎症和细胞死亡的重要调节因子,在天然免疫和免疫炎性疾病的发展中具有重要作用。该文就炎症体的结构与作用机制、信号调节及相关疾病等几方面的最新研究进展作一综述。 lnflammasome, a kind of polyprotein complexes, can activate caspase-1, regulate interleukin- 1β （IL-lbeta） and I L-I 8 processing and mature, thereby inducing the body＇s immune response. As the important regulatory factor of inflammation and cell death, inflammasome plays an important role in innate immunity and inflammatory disease development. In this review, we focus on the recent progress in the studies of the structure of inflammasome, mechanism of inflammation and related diseases and so on.
作者 吴丹 黄志伟
机构地区 哈尔滨工业大学生命科学与技术学院
出处 《中国细胞生物学学报》 CAS CSCD 北大核心 2013年第10期1426-1433,共8页 Chinese Journal of Cell Biology
基金 教育部2011新世纪优秀人才支持计划 哈工大百人计划资助的课题~~
关键词 炎症休 炎症 免疫反应 白细胞介素-1Β inflammasome inflammation immune response IL-1β
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献88

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共引文献2

同被引文献43

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引证文献6

二级引证文献37

中国细胞生物学学报
2013年 第10期

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