摘要
以间苯二酚和乙酰乙酸乙酯为原料,氨基磺酸为催化剂,超声波辐射下合成了7-羟基-4-甲基香豆素,其结构经IR和1 H NMR表征。考察了超声波辐射功率和辐射时间及催化剂用量等因素对反应的影响。结果表明,在80 W辐射反应40min,间苯二酚11g(0.1mol),n(间苯二酚)∶n(乙酰乙酸乙酯)∶n(氨基磺酸)=1.0∶1.1∶0.1条件下,7-羟基-4-甲基香豆素的收率到达95%以上。
7-Hydroxy-4-methyl coumarin was synthesized with sulfamic acid as catalyst under ultrasonic irradiation using resorcinol and ethyl acetoacetate as the raw material.Its structure was confirmed by IR and1 H NMR.The effects of ultrasonic irradiation power,irradiation time and amount of catalyst on the reaction were investigated.The results showed that when the radiation power was 80 W,the reaction time was40 min,the amount of resorcinol was 11g（0.1mol）,and n（resorcinol）∶n（ethyl acetoacetate）∶n（amino acid）=1.0∶1.1∶0.1,the yield reached above 95%.
出处
《化学世界》
CAS
CSCD
北大核心
2014年第11期688-691,共4页
Chemical World
基金
江苏省第四期"333高层次人才培养工程"第三层次培养对象项目(苏人才办2011第8号)
