摘要
目的探讨胰岛素强化治疗对2型糖尿病(T2DM)患者血清CA19-9、hs-CRP的影响,以及CA19-9与血糖、hs-CRP相互关系。方法将1 15例T2DM患者根据入院时血清CA19-9水平分为阳性组(46例)和阴性组(69例);分别于入院第2天、胰岛素强化治疗后检测糖化血红蛋白(HbA_1c)、CA19-9、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、hs-CRP水平。结果 CA19-9阳性组入院时CA19-9为(68.45±27.73)U/ml,CA19-9阴性组入院时CA19-9为(26.85±10.50)U/ml,两组间差异有统计学意义(P<0.05)。两组间HbA_1c、空腹血糖、hs-CRP差异均有统计学意义(均P<0.05)。胰岛素强化治疗能有效降低两组HbA_1c、空腹血糖、hs-CRP和阳性组CA19-9,治疗前后差异均有统计学意义(均P<0.05)。CA19-9与FPG、hs-CRP、HbA_1c均呈正相关(均P<0.05)。结论 CA19-9阴性或阳性T2DM患者采用胰岛素强化治疗均能有效控制血糖,使hs-CRP、CA19-9、HbA_1c水平降低。
Objective To investigate serum carbohydrate antigen 199（CA19- 9） and C- reactive protein levels in patients with type 2 diabetes mel itus （T2DM） after intensive insulin therapy. Methods One hundred and fifteen T2DM patients received intensive insulin therapy, including 46 patients with negative serum CA19- 9 and 69 with positive CA19- 9 at admission. The lev-els of fasting blood glucose（FPG）, glycosylated hemoglobin（HbA1c）, total cholesterol（TC）, triglyceride（TG）, high density lipopro-tein cholesterol（HDL- C）, low density lipoprotein cholesterol（LDL- C） and hypersensitive C- reactive protein （hs- CRP） were de-tected at d2 of admission and the end of intensive insulin therapy. Results The mean serum CA19- 9 levels in positive and negative groups were 68.45±27.73U/ml and 26.85±10.50U/ml, respectively （P〈0.05）;and there were significant differences in FBG, HbA1c and hs- CRP levels between two groups before treatment. Intensive insulin therapy significantly lowered FBG, HbA1c and hs- CRP levels in both groups and the levels of CA19- 9 in positive group（P＆lt;0.05）. Serum CA19- 9 was positively correlated with FBG, HbA1c and hs- CRP levels （P〈0.05）. Conclusion Insulin intensive therapy can control blood glucose effectively and decrease hs- CRP and HbA1c levels in T2DM patients with positive or negative CA19- 9.
出处
《浙江医学》
CAS
2014年第19期1635-1637,共3页
Zhejiang Medical Journal
关键词
糖尿病
胰岛素强化治疗
糖类抗原199
超敏C反应蛋白
空腹血糖
糖化血红蛋白
Diabetes mel itus
Insulin intensive treatment
Carbohydrate antigen 199 hypersensitive
C- reactive protein
Fasting plasma glucose
Glycosylated hemoglobin
