摘要
目的探讨糖尿病患者糖化血红蛋白（HbA1c）及糖化血清白蛋白（GA）对血清CA199水平的影响。方法募集29例正常糖耐量（NGT）个体及371例住院糖尿病患者，其中糖尿病患者按HbA1c水平分为良好（〈6．5％）、尚可（6．5％～7．5％）、控制差（〉7．5％）3组。比较4组CA199水平；分别计算HbA1c和GA与CA199的相关性；以性别、年龄、病程、体质指数，总胆固醇，甘油三酯，高密度脂蛋白胆固醇，低密度脂蛋白胆固醇，空腹血糖（FBG），HbA1c、CA为自变量，进行逐步多元回归分析，比较各变量对CA199的影响程度。结果（1）HbA1c控制差组的CA199水平显著高于HbA1c尚可及良好组；（2）HbA1c与CA199相关（r=0．394，P=0．000），GA与CA199相关（r=0．381，P=0．000）；（3）回归分析显示HbA1c的标准回归系数为0．364（P=0．000）。结论（1）血糖控制差的糖尿病患者CA199水平明显高于血糖控制尚可及良好的患者；（2）CA199与FBG、餐后2h血糖、HbA1c及GA水平呈显著正相关；（3）HbA1c是影响CA199的独立危险因素，糖尿病患者CA199升高与血糖长期控制不佳有密切关系。
Objective To investigate the effect of hemoglobin A1c （HbA1c） and glycated albumin （GA） on serum CA199 in diabetic patients. Methods 29 NGT matched control subjects and 371 hospitalized diabetic patients were enrolled. Diabetic patients were divided into satisfactory group （ 〈6. 5% ）, general group（6. 5%-7. 5% ）and dissatisfactory group（ 〉7.5% ）by the level of HbA1c. The levels of serum CA199 among three groups were compared. The relationship between HbA1c and CA199, GA and CA199 was analysed. Multiple stepwise regression analysis was performed to compare the effect of different variables on CA199 as the independent variables were sex, age, duration, TC, TG, HDL, LDL, FBG, PBG, HbA1c and GA. Results （1） CA199 level of the group of HbA1c above 7.5% was significantly higher than the group of HbA1c between 6. 5% and 7. 5% and the group of HbA1c less than 6.5%. （2） The coefficient of correlation between HbA1c and CA199 was 0. 39d（P =0. 000）, and that was 0. 381 between GA and CA199 （ P = 0. 000 ） . （ 3 ） Multiple stepwise regression analysis show standard regression coefficient of HbA1 c is 0. 364 （ P = 0. 000）. Conclusion （ 1 ） CA199 level of diabetic patient in poor glucose control was significantly higher than the patient in good control. （2） CA199 was positively correlated with FBG, PBG, HbA1c and GA. （ 3 ） HbA1c is the independent risk factor of CA199. The elevated CA199 in diabetic patient has close relationship with poor glucose control in a long period.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2010年第6期394-396,共3页
National Medical Journal of China
基金
上海市糖尿病重点实验室建设项目（08DZ2230200）
