摘要
目的 通过对比检测宫颈癌患者、子宫肌瘤患者及健康对照者血清中白细胞介素-6（IL-6）的表达水平,分析IL-6在子宫颈癌患者血清中的临床意义.方法 收集53例子宫颈癌患者、43例子宫肌瘤患者及50例健康对照者的外周血,分离得到血清,后用ELISA方法检测收集血清中IL-6的浓度,并分析宫颈癌患者血清中IL-6的表达水平与宫颈癌患者的年龄、肿瘤大小、病理分级、临床分期等之间的相关性,后判断IL-6在子宫颈癌患者中的临床意义.结果 宫颈癌患者血清中IL-6的表达水平显著高于其他两组（P＜0.05）;低分化肿瘤患者血清中IL-6的浓度显著高于高分化肿瘤患者（P＜0.05）;临床分期为Ⅲ、Ⅳ期的患者血清中IL-6的水平要显著高于分期较早的患者;线性回归结果显示,IL-6每上升10 ng/ml,宫颈癌的直径平均增大0.902 mm;Logistic回归分析结果显示,IL-6每上升10 ng/ml,发生宫颈癌的风险升高30.3％ （P ＜0.05）.结论 IL-6作为机体重要的炎症细胞因子之一,在宫颈癌患者血清的中表达明显升高,且其水平与肿瘤的相关特性如大小、病理分级、临床分期等均密切相关,从而提示其可能在宫颈癌的发生、发展过程中扮演着重要的角色,对其水平的检测可能会有助判断宫颈癌患者肿瘤特性、病情监测等过程中.
Objective To detect the expression level of interleukin-6 （IL-6） in serum of patients with cervical carcinoma,hysteromyoma and healthy controls,and thus to analyze its potential clinical significance in patients with cervical carcinoma.Methods The peripheral blood from 53 cervical carcinoma patients,43 hysteromyoma patients and 50 healthy controls were collected,and the serum from each sample was isolated,then IL-6 in serum was detected by ELISA kit.The relationship between IL-6 level in serum of patients with cervical carcinoma and age,tumor size,pathological grade,clinical stages were also analyzed.Results Cervical serum IL-6 expression level was significantly higher than the other two groups （P ＜ 0.05） ; The level of IL-6 in patients with poorly differentiated tumors was significantly higher than that in patients with higher differentiated tumor （P ＜ 0.05） ; and the level of IL-6 in patients with clinical stage Ⅲ and stage Ⅳ were significantly higher than that in patients with earlier stages; linear regression showed IL-6 increased by 10 ng/ml when the average diameter of cervical cancer increased 0.902 mm ; logistic regression analysis showed if IL-6 increased by 10 ng/ml,the risk of cervical cancer increased 30.3 ％ （P ＜ 0.05）.Conclusions IL-6,as an important inflammatory cytokines,is found to be significantly increased in serum of cervical carcinoma patients,and the expression level of IL-6 is correlated with tumor size,pathological grade,clinical stage,which reveals that IL-6 plays an vital role in the development of cervical carcinoma.The detection of IL-6 could be helpful to determine the tumor property and monitor the cancer patients.
出处
《中国实用医刊》
2014年第23期20-22,共3页
Chinese Journal of Practical Medicine
