摘要
目的探讨改进《中国药典》2010年版卡托普利片中卡托普利二硫化物的测定方法。方法以0.01mol·L-1磷酸二氢钠-甲醇-乙腈(70∶25∶5)(用磷酸调节至pH 3.0)为流动相A,甲醇为流动相B;梯度洗脱。结果二硫化物的保留时间由药典方法的49.8min缩短到18.9min。结论本文方法较药典方法快捷,可为标准改进提供参考。
Objective To discuss the improvement of testing for captopril-disulphide in Captopril Tablets in Chinese Pharmacopoeia（2010edition）.Methods The mobile phase A was 0.01 mol·L-1sodium dihydrogen phosphate solution-methanol-acetonitrile（75∶25∶5）（adjusted to pH 3.0 with phosphate）;the mobile phase B was 100% methanol for gradient elution.Results The retention time of the disulphide was reduced from 49.8 min by pharmacopoeia method to 18.9 min by this method.Conclusion The method in this paper was quick and timesaving compared to the pharmacopoeia method,and can provide a reference for standard improvement.
出处
《中国药事》
CAS
2014年第11期1252-1256,共5页
Chinese Pharmaceutical Affairs
关键词
卡托普利片
卡托普利二硫化物
梯度洗脱
方法改进
Captopril Tablet
captopril-disulphide
gradient elution
improvement of method
