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子宫内膜异位症的异位内膜雌激素产生、代谢情况分析 被引量:5

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摘要 目的:研究分析子宫内膜异位症异位内膜雌激素产生、代谢的具体情况。方法:通过RT-PCR、免疫组化法对134例卵巢子宫内膜异位囊肿患者进行检测,观察异位子宫内膜、在位内膜组织中17β-HSDⅡmRNA、蛋白质、P450A mRNA的表达,同时与70例正常子宫内膜情况相对比。结果:70例健康者正常子宫内膜没有P450 AmRNA、17β-HSD II mRNA在增生晚期的微量表达,在分泌期晚期升至高峰;在位内膜显示P450AmRNA的微弱表达,而17β-HSD II mRNA的表达情况近似于正常子宫内膜,强度比较小。134例卵巢异位内膜均发现P450A mRNA的表达,但是17β-HSD II mRNA的表达不足。结论:子宫内膜异位症患者的异位内膜可以产生雌激素,但是存在局部雌激素代谢缺陷,所形成的雌激素微环境是造成异位内膜生长的重要因素。
作者 杨年红
出处 《中国妇幼保健》 CAS 北大核心 2014年第33期5406-5407,共2页 Maternal and Child Health Care of China
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