摘要
目的 探讨一期开放性植骨联合负压封闭引流治疗感染性骨不连的手术效果.方法 将36只新西兰大白兔随机分为A、B两组,两组兔均行感染性骨不连造模,造模成功后A组行一期开放性植骨,B组行二期开放性植骨,两组兔创面均行人工皮覆盖行负压封闭引流,比较两组的创面感染细菌数量、骨折愈合率、创面愈合率等指标.结果 植骨后2周时,A组骨折愈合数10只,创面愈合数6只,B组骨折愈合数14只,创面愈合数12只;植骨后4周时,A组骨折愈合数16只,创面愈合数13只,B组骨折愈合数18只,创面愈合数17只;植骨后8周时,A组感染数3只,骨折愈合数18只,创面愈合数17只,B组感染数1只,骨折愈合数18只,创面愈合数18只.所以两组在创面感染控制、骨折愈合率、创面愈合率比较差异无统计学意义（P＞0.05）,X线片上观察,两组兔骨不连均已临床愈合,但A组创面和骨折愈合时间要短于B组兔.结论 一期开放性植骨联合负压封闭引流是治疗感染性骨不连的简单有效的手术方式,效果等同于传统分期开放性植骨术手术,且可缩短治疗周期.
Objective To investing surgical results of one stage open bone grafting combined with vacuum-assisted closure for the treatment of infected nonunion in rabbit model.Methods Thirty-six New Zealand white rabbits were randomly divided into groups A and B,and infected nonunion models were made in all of the animals.The rabbits in group A were treated with one stage open bone grafting combined with vacuum-assisted closure,and those in group B given two stage open bone grafting combined with vacuumassisted closure.At 2nd,4th,and 8th week,X-ray examination was done,at the same time,the rate of fracture healing and wound healing were counted.Results After two weeks,the number of fracture healing was 10 and wound healing was 6 in group A,and the number of fracture healing was 14 and wound healing was 12 in group B.After four weeks,the number of fracture healing was 16 and wound healing was 13 in group A,and the number of fracture healing was 18 and wound healing was 17 in group B.After eight weeks,the number of infected animals was 3,fracture healing was 18 and wound healing was 17 in group A,and the number of infected animals was 1,fracture healing was 18 and wound healing was 18 in group B.There was no significant difference in the rate of fracture healing and wound healing （P 〉 0.05）,and the nonunions in two group were clinically healed,but the healing time in group A was shorter than in group B.Conclusion One stage open bone grafting combined with vacuum-assisted closure is a simple and effective surgical method to treat the infected nonunion,as the same effect as traditional surgical staging,but the treatment duration is shorter.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2014年第11期2524-2526,共3页
Chinese Journal of Experimental Surgery
基金
武汉市科技局科技攻关计划资助项目（201260523173-1）
武汉大学研究生资助科研项目（2012303020207）
