摘要
目的：比较阿托伐他汀联合氨氯地平与氨氯地平单药治疗高血压临床效果。方法随机选择原发性高血压患者116例，根据治疗方法分为对照组和观察组，对照组60例，给予氨氯地平治疗；干预组56例，在对照组基础上应用阿托伐他汀治疗。观察治疗前后收缩压和舒张压；颈动脉动脉内中膜厚度（IMT），并检测颈动脉有斑块面积；血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）及尿微量白蛋白（mAlb）。结果观察组和对照组治疗后收缩压分别为（138．51±12．90）mmHg和（147．62±13．45）mmHg，均低于治疗前（t＝12．67、10．35，均P＜0．05），且观察组治疗后低于对照组（t＝7．82，P＜0．05）；观察组和对照组治疗后舒张压分别为（90．17±4．30）mmHg和（93．63±6．26）mmHg，均低于治疗前（t＝9．86、11．03，均P＜0．05），且观察组治疗后低于对照组（t ＝5．14，P＜0．05）；观察组和对照组治疗后 IMT 分别为（0．73±0．34）mm和（0．85±0．39）mm，均低于治疗前（t＝6．60、6．29，均P＜0．05），且观察组治疗后低于对照组（t＝5.74，P＜0．05）；观察组和对照组治疗后斑块面积分别为（12．02±1．45） mm^2和（13．52±1．86） mm^2，均低于治疗前（t＝8．13、8．59，均P＜0．05），且观察组治疗后低于对照组（t＝6．22，P＜0．05）；观察组和对照组治疗后mAlb、TC和LDL-C均低于治疗前（t＝7．65、8．01、6．08、6．44、5．94、6．02，均P＜0．05），且观察组治疗后低于对照组（t＝5．86、5．37、5．63，均P＜0．05）；两组不良反应差异无统计学意义（χ^2=1．08，P＞0．05）。结论阿托伐他汀联合氨氯地平治疗高血压效果显著，且无明显不良反应，值得临床推广应用。
Objective To explore the clinical effect between atorvastatin combined with amlodipine and amlodipine monotherapy for the treatment of hypertension .Methods 116 patients with primary hypertension were randomly selected.According to treatment methods, they were divided into the control group and the observation group,60 cases in the control group was given amlodipine therapy.56 patients in the intervention group,with atorvasta-tin treatment on the basis of the control group.Systolic and diastolic blood pressure before and after the treatment, carotid artery intima-media thickness （IMT） were observed,and carotid plaque area,serum total cholesterol （TC）, low density lipoprotein cholesterol （ LDL-C） and urinary albumin （ mAlb） were detected.Results After treatment, systolic blood pressure of the observation group and the control group were （138.51 ±12.90） mmHg and （147.62 ± 13.45）mmHg,lower than those before treatment（t=12.67,10.35,all P〈0.05）,and the patients of the observation group lower than the control group （t=7.82,P〈0.05）.The diastolic blood pressure of the observation group and the control group after treatment were （90.17 ±4.30）mmHg and （93.63 ±6.26）mmHg, lower than that of the before treatment（t=9.86,11.03,all P〈0.05）,the observation group was lower than that in the control group （t=5.14, P〈0.05）.IMT of the observation group and the control group were （0.73 ±0.34）mm and （0.85 ±0.39）mm,lower than those before treatment（t=6.60,6.29,all P〈0.05）,and that in the observation group was lower than that in the control group （t=5.74,P〈0.05）.The plaque area of the observation group and the control group patients were （12.02 ±1.45）mm2 and （13.52 ±1.86）mm2,lower than those before treatment（t=8.13,8.59,all P〈0.05）,and the patients in the observation group was lower than the control group （t=6.22,P〈0.05）.mAlb,TC and LDL-C of the observation group and the control group after treatment were lower than those before treatment（t=7.65,8.01, 6.08,6.44,5.94,6.02,all P〈0.05）,and the patients in the observation group was lower than the control group,the difference had statistical significance （t=5.86,5.37,5.63,all P〈0.05）.The adverse reactions of two groups had no significant difference （χ^2=1.08,P〉0.05）.Conclusion There is a good clinical effect of atorvastatin combined with amlodipine for the treatment of hypertension and there is no obvious adverse reactions,which is worthy of clinical application.
出处
《中国基层医药》
CAS
2014年第22期3433-3435,共3页
Chinese Journal of Primary Medicine and Pharmacy
