摘要
目的 观察卵巢Sertoli-Leydig细胞瘤的临床病理及免疫表型特点,探讨其诊断、鉴别诊断及预后.方法 对7例卵巢Sertoli-Leydig细胞瘤进行光镜及免疫组化检测,并结合临床及病理特点进行分析.结果 7例Sertoli-Leydig细胞瘤的平均年龄为31.00±13.52岁,均发生于一侧卵巢,平均直径9.93±6.58 cm.镜下Sertoli细胞排列呈管状或条索状,细胞核圆形或卵圆形,部分为短杆状,胞质淡染或透明;性腺间质细胞排列密集,核浆比例较大,核染色深,细胞界限不清;两种细胞逐渐过渡移行.Leydig细胞单个或成簇出现于间质内,核小,具有丰富的嗜酸性胞质.随访10-96个月,所有患者无瘤存活.结论 本病罕见,病理诊断尤其在术中冷冻诊断有一定的难度.卵巢支持间质细胞肿瘤较少有术前明确诊断,部分患者年龄轻,有保留生育功能要求,术中冷冻明确诊断具有较重要意义.
Objective To observe the clinicopathological and immunophenotype characteristics of Sertoli-leydig cell tumour,and to explore the diagnosis,differential diagnosis and prognosis of Sertoli-leydig cell tumour （SLCTs）.Methods 7 cases of SLCTs were examined by light microscopy and immunochemistry.Results The median age of the patients with SLCTs was 31.00 ± 13.52 years.The cases of this group all occurred in unilateral ovaries,with an average size of 9.93 ± 6.58 cm.The tumors were consisted of sertoli cells and gonad interstitial cells.Sertoli cell had spherical or oval nucleus,some of short rod nucleus,and had light coloured or transparent cytoplasm.Gonad interstitial cells arranged densely,with nuclear and cytoplasm in the high ratio,deep nuclear staining,and the cell boundaries were not clear.Two kinds of cells were gradually transformation.Ledig cells singly or in clusters appeared in the interstitial tissue,with small nuclei,and abundant eosinophlilc cytoplasm.With a follow-up of 10-96 months,all patients were living with free of tumor.Conclusion Sertoli-leydig cell tumor is rare and can not be clearly diagnosed preoperatively.Especially in the intraoperative frozen pathological diagnosis is difficult.While some younger patients require to preserve fertility function,the intraoperative frozen section is important for exact diagnosis.
出处
《诊断病理学杂志》
CSCD
北大核心
2014年第10期601-604,共4页
Chinese Journal of Diagnostic Pathology
