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生物响应MRI对比剂的研究进展 被引量:1

Research progress in bio-responsive MRI contrast agent
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摘要 不同组织和疾病都存在特异性的生物信号。开发能对这些生物信号响应的磁共振成像(MRI)对比剂,不仅有望增加MRI检测疾病的灵敏度,而且能够对病变产生的信号进行分子成像,提高疾病诊断的准确度。该文详细综述了白蛋白、pH、金属离子、酶、氧化还原以及其他生物分子等响应对比剂的最新进展,对未来的研究方向做了展望。 Different tissues and diseases have specific biological signals. The development of magnetic resonance imaging (MRI) contrast agents responding to these signals can not only improve the sensitivity of disease detection by MRI, but also increase the accuracy of disease diagnosis through molecular imaging of these disease signals. This paper gives a review of MRI contrast agents responding to albumin, pH, metal ion, enzyme, redox and other biological signals with the focus on the latest developments and perspectives.
出处 《磁共振成像》 CAS CSCD 2014年第5期381-386,共6页 Chinese Journal of Magnetic Resonance Imaging
基金 国家自然科学基金(编号:21174128) 教育部博士点基金(编号:20090101120159) 浙江省钱江人才计划(编号:2010R10050)
关键词 磁共振成像 造影剂 Magnetic resonance imaging Contrast media
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  • 1俞开潮,王国平,丁尚武,叶朝辉.用于磁共振成像对比增强的造影剂研发进展[J].波谱学杂志,2004,21(4):505-525. 被引量:18
  • 2张善荣,任吉民,裴奉奎.磁共振成像造影剂的一些进展[J].化学进展,1995,7(2):98-112. 被引量:18
  • 3Lauterbur P C.Image formation by induced local interaction:examples employing nuclear magnetic resonance[J].Nature,1973,242:190-191.
  • 4Damadian R,Minkoff L,Goldsmith M,et al.Field focusing nuclear magnetic resonance (FONAR):visualization of a tumor in a live animal[J].Science,1976,194:1 430-1 432.
  • 5Buxton R.Introduction to functional magnetic resonance Imaging:Principles and Techniques[M].Cambridge University Press,2002.
  • 6Blümich B.NMR Imaging of Materials[M].Oxford:Clarendon Press,2000.
  • 7Callaghan P T.Principles of Nuclear Magnetic Resonance Microscopy[M].Oxford:Clarendon Press,1991.
  • 8Liang Z P,Lauterbur P C.Principles of magnetic resonance maging,A signal processing perspective[M].New York:Spie Op-tical Engineering Press,2000.
  • 9Zhu Dong-lin(俎栋林).Magnetic Resonamce Imaging(核磁共振成像学)[M].Beijing(北京):Higher Education Press(高等教育出版社),2004.
  • 10Lauffer R B.Paramagnetic metal complexes as water proton relaxation agents for NMR imagining:theory and design[J].Chem Rev,1987,87:901-927.

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