摘要
随着磁共振影像技术的快速发展,MRI在医学领域得到广泛应用,已成为目前临床常规影像诊断方法和手段之一。但MRI对信号探测的敏感性较低,因此需要某些介质在靶组织内大量聚集以达到信号扩增的目的,于是磁共振成像对比剂应用而生。磁共振造影剂(对比剂)可以提高成像分辨率,增加正常与病变组织的成像对比度,从而提高磁共振诊断疾病的敏感性和特异性,目前逐日成为众多学者研究关注的焦点之一。超顺磁性氧化铁纳米粒是一种新型的磁共振对比剂,它的有效成份为纳米级的Fe3O4或Fe2O3晶体核心,主要通过缩短组织中成像水质子的弛豫时间从而加快组织弛豫速率,得以提高正常组织和病灶组织的成像信号对比度,对肝、脾、淋巴结病变的成像效果好,安全性高,能够显著提高小病灶的检出,从而达到早期诊断发现疾病的目的。本文主要就磁共振造影剂的原理、分类及研究进展,尤其是超顺磁性氧化铁在肝脏疾病诊断中的应用进行了综述,并且对磁共振造影剂的未来发展趋势进行了展望。
With the rapid development of technology of magnetic resonance imaging（MRI）,MRI widely used in the medical field has been one of routine clinical diagnostic methods and means of imaging.However,MRI,because of the low sensitivity of signal detection,needs some large concentration of media in the targeted tissue to achieve the purpose of signal amplification.So the MRI contrast agent was developed.Magnetic resonance contrast agents can improve imaging resolution to increase the contrast of normal and abnormal tissue,so as to improve the sensitivity and specificity of MRI diagnosis of diseases.Therefore many scholars focus attention on the contrast agent.Superparamagnetic iron oxide nanoparticles（SPIO）,with an active ingredient of nanoscale Fe3O4or Fe2O3crystal core,is a new type of magnetic resonance contrast agent.It can speed up tissue relaxation rate by shortening the relaxation time of water protons and effectively improve tissue imaging signal contrast on the liver,spleen,lymph node lesion which significantly improve the detection of small lesions to achieve the purpose of the early diagnosis of the disease.In this paper,It was systematically reviewed.of the principles of MRI contrast agent,classification and the research progress,especially application of SPIO in the diagnosis of liver disease.The future development of the MRI contrast agent was outlooked.
出处
《现代生物医学进展》
CAS
2013年第16期3186-3189,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(50603015)
关键词
磁共振造影剂
超顺磁性氧化铁
研究进展
MRI contrast agent
Superparamagnetic iron oxide
Research progress
