摘要
目的研究阿苯达唑前体胶束在猪体内的药动学。方法采用RP-HPLC法、以甲苯咪唑为内标,测定ig给予英系纯种长白猪阿苯达唑胶束水化溶液和阿苯达唑片剂生理盐水混悬液后,血浆中阿苯达唑、阿苯达唑亚砜、阿苯达唑砜的血药浓度,并计算药动学参数。结果阿苯达唑前体胶束及片剂的血药-时间曲线均为二室模型;二者药动学参数的差异具有统计学意义(P<0.05)。前体胶束相对于片剂的相对生物利用度为230.45%。结论前体胶束在胃肠道的滞留时间增长,吸收增加,清除率较低,延长了药物在组织器官中的消除时间,提高了生物利用度。
OBJECTIVE To study the pharmacokinetic of Albendazole pro - micelles in landrace pig. METHODS Plasma concen- tration of Albendazole, Albendazole sulfoxide, Albendazole sulfone were determined by RP - HPLC, mebendazole as internal standard, after oral administration of suspension of Albendazole tablets saline solution and Albendazole pro - micelles hydration solution, and calculate pharmacokinetics parameter. RESULTS The concentration - time cure of Albendazole pro - micelles and Albendazole tablets were fitted to a two - compartment model and these main pharmacokinetic parameters obtained showed statistical significance. The relative bioavailability of Albendazole pro - micelles compared with tablet by oral administration were 230.45%. CONCLUSION Albendazole pro - micelles, with longer residence time in gastrointestine and low clearance rate, could increase the gastrointestinal absorption, prolong the residence time of Albendazole sulfoxide and sulfone in the blood after oral administration, so it could improves the bioavailability.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2014年第5期556-558,共3页
West China Journal of Pharmaceutical Sciences
基金
国家自然科学基金资助项目(批准号:30260119)
