摘要
背景:由于内皮祖细胞的高分化潜能和参与内皮修复及血管生成,其在治疗糖尿病患者血管并发症方面有广阔前景。目的:针对糖尿病血管并发症患者内皮祖细胞的变化及内皮祖细胞在糖尿病血管并发症治疗中的应用做一综述。方法:应用计算机检索1997年1月至2014年5月PubMed和CNKI相关文献,检索词为"endothelial progenitor cells,diabetic vascular complication",和"内皮祖细胞,糖尿病,糖尿病血管并发症"共检索到英文文献147篇,中文文献26篇,筛选纳入符合标准的文献44篇。结果与结论:由于氧化应激增加,抗氧化系统损害,一氧化氮合成减少,低氧应答缺失等机制,导致糖尿病患者内皮祖细胞数量减少,动员不足,黏附、迁移、成血管能力受损,使受损血管内皮修复和血管新生障碍,最终导致了糖尿病血管并发症的发生。而移植健康内皮祖细胞给糖尿病血管并发症患者,或改变患者的内皮祖细胞数量和功能,促进其动员和向缺血组织迁移能使病情得到不同程度的改善,已成为糖尿病血管并发症新的治疗策略。
BACKGROUND： Because of the high potential of differentiation and involvement in endothelial repair and angiogenesis, endothelial progenitor cells have broad prospects in the treatment of diabetic vascular complications. OBJECTIVE： To review the changes of endothelial progenitor cells in patients with diabetic vascular complications and the therapeutic application of endothelial progenitor cells in diabetic vascular diseases. METHODS： We searched PubMed database and CNKI database with the key words of ＂endothelial progenitor cells, diabetes mellitus, diabetic vascular complications＂ in English and Chinese, respectively, for relevant articles published from January 1997 to May 2014. A total of 147 English literatures and 26 Chinese literatures were searched, and finally 44 papers were involved in the analysis. RESULTS AND CONCLUSION： Because of increased oxidative stress, impairment of the antioxidant system,reduction of nitric oxide synthesis, and the loss of response to hypoxia, the number and mobilization of endothelial progenitor cells in diabetic patients are reduced, and their capacity of adhesion, migration, and angiogenesis are impaired, which lead to diabetic vascular complications. Transplantation of healthy endothelial progenitor cells can improve the number and function of endothelial progenitor cells, and promote the mobilization and chemotaxis of endothelial progenitor cells to ischemic tissue in patients with diabetic vascular diseases, which has become the new therapeutic strategy for diabetic vascular complications.
出处
《中国组织工程研究》
CAS
CSCD
2014年第32期5214-5219,共6页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金(81273568)
甘肃省自然科学基金(1107RJZA114)~~
