摘要
目的:探讨大环内酯类药物在治疗慢性鼻-鼻窦炎中的作用。方法:将165例慢性鼻-鼻窦炎患者随机分为大环内酯类药物治疗组(80例)和头孢类药物治疗组(85例),记录2组的疗效。观察大环内酯类药物对难治性慢性鼻-鼻窦炎的疗效。结果:大环内酯类药物治疗组和头孢类药物治疗组的有效率分别为81.1%、77.8%(P>0.05)。18例头孢类药物治疗无效者采用大环内酯类药物治疗3个月,治疗前后积分(45分、13分)比较差异有统计学意义(P<0.01);14例大环内酯类药物治疗无效者采用头孢类药物治疗,治疗前后积分(35分、28分)比较差异无统计学意义(P>0.05)。结论:长期低剂量应用大环内酯类药物对慢性鼻-鼻窦炎患者有良好疗效,特别对于难治性慢性鼻-鼻窦炎有明显的疗效。
Objective： Invastigation of macrolides in the treatment of drug effects in chronic rhinosinusit. Meth- od：The 165 patients with chronic rhinosinusit were randomly divided into 80 cases of macrolides drug group and 85 cases of cephalosporins group, and therapeutic effect was observed. The therapeutic effect of macrolicles was also observed in refractory chronic rhinosinusit. Result： Comparing macrolides group and cephalosporins group,there is not statistically significant（P^0.05）. Treatment with macrolides cefixime tablet ineffective treatment of patients for 3 months, compared before and after treatment was statistically significant （P〈0.01）. Treatment with cefixime tablet macrolides ineffective treatment of patients for 3 months, compared before and after treatment was not statistically significant （P〉0.05）. Conclusion： Long-term low-dose applications of macrolides have a good effect in patients with chronic rhinosinusit, particularly for refractory chronic rhinosinusit have a significant effect.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2014年第17期1289-1291,共3页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
