摘要
目的:分析生脉散汤剂及其配方颗粒主要指标性成分的差异,并应用HPLC色谱法建立配方颗粒的特征图谱,为中药配方颗粒能否代替复方汤剂提供依据。方法:采用HPLC色谱法,比较生脉散配方颗粒和传统汤剂两者特征图谱的差别,并通过相似度软件分析两者的相似性。结果:本色谱条件下生脉散配方颗粒各成分得到较好的分离,特征图谱有9个特征峰组成,汤剂中五味子醇甲等指标性成分与配方颗粒接近。结论:本方法可同时分离生脉散及其配方颗粒中各特征成分,配方颗粒与传统剂型成分差异统计学意义。
Objective：To analyze the differences of main indicators ingredients of Shengmaisan decoction and its concentrated granules, to build characterized map of Shengmaisan concentrated granules by HPLC chromatography,so as to provide the reference for TCM con-centrated granules to replace the decoction preparation.Methods：HPLC chromatography was used to compare the characteristic spectrum difference between Shengmaisan decoction and its concentrated granules.Analysis was conducted on the similarity of the two by the simi-larity software.Results：Shengmaisan concentrated granules got a better separation of the components under the chromatographic condi-tions,and the characteristic spectrum had nine peaks.Schizandrin and other Index components levels in Shengmaisan decoction were roughly the same as those in the concentrated granules.Conclusion：This method can simultaneously separate index components of Sheng-maisan decoction and itsTCM concentrated granules.There is no significant difference between Shengmaisan decoction and its TCM con-centrated granules.
出处
《世界中医药》
CAS
2014年第8期1089-1092,共4页
World Chinese Medicine
基金
广东省中医药局建设中医药强省科研课题(编号:20112084)
广东省教育部产学研结合项目(编号:2012B091100183)
关键词
生脉散
配方颗粒
特征图谱
Shengmaisan
TCM concentrated granules
Characteristic spectrum
