摘要
目的采用Meta分析方法对大环内酯类抗生素治疗哮喘急性发作的疗效进行系统评价。方法以“大环内酯类抗生素”和“哮喘”为检索词，检索CNKI、维普资讯和PubMed数据库，并手工检索美国临床肿瘤学会论文集。根据纳入与排除标准筛选文献，提取数据并评价质量，用ReviewManager5．0软件进行Meta分析，同时进行敏感性分析及发表偏倚的评估。结果本研究共纳入文献6篇，经Meta分析，大环内酯类抗生素可明显改善哮喘发作时症状（OR=3．10，95％CI：1．71～5．64），总体效应检验Z=3．71，P=0．0002。结论大环内酯类抗生素可有效减少哮喘的反复发作。
Objective To assess the efficacy of macrolides antibiotics in the treatment of asthma acute attack through Meta-analysis of published pertinent articles scientifically. Methods Pertinent literatures on macrolides antibiotics related with asthma acute attack were searched in PubMed, CNKI and WeiPu Data. According to the inclusion and exclusion criteria, the data were extracted and the methodological quality was evaluated. Then the Meta-analysis was conducted by Review Manager 5.0 software, and the sensitivity analysis and publication bias were evaluated at the same time. Results Six randomized controlled trials were included, and the result combined OR values and 95% CI was that macrolides antibiotics could improve the symptom of asthma acute attack [OR=3.10, 95%CI （1.71, 5.64）, Z=3.71, P=0.000 2]. Conclusion Macrolides antibiotics can significantly improve the clinical efficacy of asthma acute attack.
出处
《世界临床药物》
CAS
2014年第8期483-486,共4页
World Clinical Drug
