摘要
目的探讨帕金森病患者睡眠障碍临床特征及影响因素。方法 66例原发性帕金森病患者根据发病类型分为震颤为主型(A组)和姿势异常步态障碍(PIGD)为主型(B组),每组33例。对2组患者采取面对面问卷调查方式进行相关量表评分,包括帕金森睡眠量表(PDSS)、简易神经状态量表(MMSE)、汉密尔顿抑郁评价量表(HAMD)、统一帕金森病评定量表-运动检查(UPDRS-Ⅲ)"关"期评分,并分析影响各组睡眠障碍的相关因素。结果 B组患者UPDRS-Ⅲ总分、HAMD总分均明显高于A组,MMSE总分明显低于A组,差异有统计学意义(P<0.05或P<0.01)。A组PDSS评分显著高于B组,差异有统计学意义(P<0.05)。A组睡眠障碍发生率明显低于B组,差异有统计学意义(P<0.05)。B组患者睡眠障碍与UPDRS-Ⅲ评分、HAMD总分相关(P<0.05);A组患者睡眠障碍与MMSE总分相关(P<0.05)。结论 PIGD为主型较震颤为主型帕金森病患者更易出现睡眠障碍,可能与帕金森病不同亚型的临床异质性相关。
Objective To explore the clinical characteristics and influencing factors of sleep disorders in patients with Parkinson disease.Methods A total of 66 patients with primary Parkinson disease were equally divided into group A mainly with convulsion and group B with abnormal posture and gait disturbance （PIGD） according to different onset types.Relevant scale evaluations were taken face to face in both groups,including period ＂Guan＂ in Parkinson disease sleep scale （PDSS）,mini-mental state examination （MMSE）,Hamilton Depression Scale （HAMD） and Unified Parkinson＇s Disease Rating Scale （UPDRS-Ⅲ）,and relevant factors influencing patients＇ sleep were analyzed.Results Group B was evidently higher in UPDRS-lⅢ and HAMD scores,but obviously lower in MMSE score than A group,and the differences were significant （P ＜ 0.05 or P ＜0.01）,whereas group A was apparently higher in PDSS score,and there was significant difference （P ＜ 0.05）.Additionally,sleep disorder in group A was markedly lower than in group B （P ＜0.05）,which was connected with MMSE total score in group A （P＜0.05） and with UPDRS-Ⅲ score and HAMD total score in group B （P ＜ 0.05）.Conclusion The risk of sleep disorder is higher in Parkinson patients with PIGD than in those with convulsion,which is in potential association with the clinical characteristics of different subtypes of Parkinson.
出处
《实用临床医药杂志》
CAS
2014年第11期49-51,共3页
Journal of Clinical Medicine in Practice
关键词
帕金森病
睡眠障碍
临床特征
影响因素
Parkinson disease
sleep disorder
clinical characteristics
influencing factors
