摘要
目的 探讨雌激素受体α（ERα）、雌激素受体β（ERβ）、孕激素受体（PR）及细胞凋亡调控因子在子宫内膜息肉组织中的表达及意义.方法 选择50例子宫内膜息肉的患者为息肉组,并选择45例子宫内膜正常体检者作为对照组.采用酶联免疫测定法分别对两组的FSH、LH、E2、P、T及PRL六项水平进行检测.并对两组患者子宫内膜的ERα、ERβ、PR及Bcl-2的表达情况进行比较.结果 两组患者的FSH、LH、E2、P、T及PRL六项水平差异均无统计学意义（均P＞0.05）.增殖期的息肉组ERα、ERβ的表达水平与对照组均无统计学意义（均P＞0.05）,PR的表达水平（0.47±0.02）分,明显低于对照组的（0.53±0.02）分（t=10.383,P =0.000）,Bcl-2表达水平（0.53±0.04）分,明显高于对照组的（0.49±0.02）分（t=4.322,P=0.000）.分泌期的息肉组ERα、Bcl-2表达水平（0.46±0.07）、（0.43±0.04）分,明显高于对照组的（0.37±0.05）、（0.39±0.03）分（t=5.007,P=0.000;=3.834,P=0.000）,PR的表达水平（0.42±0.02）分,明显低于对照组的（0.46±0.01）分,两组的ERβ表达水平差异无统计学意义（t=8.486,P=0.000）.结论 ERα、Bcl-2表达水平的升高,以及PR表达水平的降低与患者发生子宫内膜息肉密切相关.
Objective To investigate the expression and significance of ERα （estrogen receptorα）,ERβ（estrogen receptorβ）,PR,and Bcl-2 of endometrial polyps.Methods 50 cases of endometrial polyp patients were studied.And 45 cases of endometrial normal subjects were selected as the control group.The enzyme-linked immunosorbent assay was used to detected the FSH,LH,E2,P,T and PRL six levels of the two groups.And endometrial ERα two groups of patients,ERβ,PR and Bcl-2 expression was studied.Results The FSH,LH,E2,P,T and PRL six levels of the two groups were no significant difference（P ＞0.05）.Polyps in patients with proliferative phase of ERα,ERβ expression levels of the normal group had no significant difference （P ＞ 0.05）,the expression level of PR（0.47 ± 0.02） point was significantly lower than that of the normal group（0.53 ± 0.02） point （t =10.383,P =0.000）,Bcl-2 expression levels（0.53 ± 0.04） point was significantly higher than that of the normal group （0.49 ± 0.02） point （t =4.322,P =0.000）.Polyps in patients with secretory phase of ERα,Bcl-2 expression levels （0.46 ± 0.07;0.43 ±0.04）point were significantly higher than that of the normal group （0.37 ± 0.05 ;0.39 ± 0.03） point （t =5.007,P =0.000; t =3.834,P =0.000）,the expression level of PR （0.42 ± 0.02） point was significantly lower than that of the normal group （0.46 ± 0.01）point（t =8.486,P =0.000）,there was no significant difference in expression levels between the two groups ERβ（P ＞0.05）.Between the two groups displayed,ERα,PR proliferative phase of the normal group and the polyp group,the expression levels of Bcl-2 were significantly higher than that of the secretory phase （P ＜ 0.05）.Conclusion The increase of the ERα,Bcl-2 expression levels,and the reduction of the level of PR expression in patients with endometrial polyps are closely related.
出处
《中国基层医药》
CAS
2014年第18期2781-2782,共2页
Chinese Journal of Primary Medicine and Pharmacy
