摘要
目的:探讨孕激素受体在黄体期不足不孕患者子宫内膜组织中的表达。方法:选取120例不孕妇女,采用抗人孕激素受体(PR)单克隆抗体,将120例患者分为LPD组56例与对照组64例,对比两组PR免疫组化测定,放射免疫法(RIA)测定黄体中期血清二醇(E2)、孕酮(P)水平。结果:两组孕激素水平比较,差异无统计学意义(P>0.05),LPD组分泌晚期子宫内膜间质细胞PR显著低于对照组,差异有统计学意义(P<0.05),分布不均,黄体中期E2水平对照组显著高于LPD组,差异有统计学意义(P<0.05)。结论:PR合成减少是由于卵巢雌激素分泌不足导致;黄体期不足不孕子宫内膜分泌不良是由于子宫内膜中PR含量下降所致。
Objective： To discuss the expression of progesterone receptor（PR） in endometrial tissue among infertile patients with luteal phase inadequacy.Methods： A total of 120 infertile women admitted to our hospital from January 2009 to April 2012 were enrolled.PR monoclonal antibody was used and 120 patients were divided into luteal phase defect（LPD） group（n=56） and control group（n=64）.The immunohistochemical tests for PR,together with serum E2 and progestogen（P） levels in midluteal phase measured by radioimmunoassay in two groups were compared.Results： No statistical difference was observed between two groups in progestogen levels（P0.05）.PR content in endometrial stromal cells during late secretion stage in LPD group is significantly lower than that in control group（P0.05）.In midluteal phase,the level of E2 in control group is significantly higher than that in LPD group（P0.05）.Conclusion： The decrease of PR synthesis is caused by insufficiency of ovarian estrogen secretion and the decrease of PR in endometrium lead to the abnormal secretion of infertile endometrium with luteal phase inadequacy.
出处
《海南医学院学报》
CAS
2013年第6期832-834,共3页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210681)~~
关键词
雌激素受体
孕激素
子宫内膜受体
黄体期不足
Endometrial receptors
Progestogen
Endometrial receptors
Luteal phase inadequacy
