摘要
目的:观察抗抑郁药联合经颅微电流刺激疗法(CES)治疗急性期抑郁症患者的疗效和安全性。方法:80例抑郁症患者,随机分为CES组和对照组各40例,2组均给予抗抑郁药,CES组还给予CES,治疗6周。采用17项汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评价症状严重程度,并进行威斯康星卡片分类测验(WCST)评估认知功能,副反应量表(TESS)评价药物不良反应。结果:CES组38例、对照组37例完成研究。2组治疗后HAMD和HAMA评分较治疗前均降低(P<0.01);第6周2组间的有效率和痊愈率差异无统计学意义(P>0.05);第4周CES组的有效率高于对照组,差异有统计学意义(P<0.05)。2组不良反应差异无统计学意义(P>0.05)。结论:CES辅助治疗抑郁症具有较好的安全性,且起效快,疗效确切。
Objective： To observe the curative effect and safety of antidepressants combined with Cranial Electrotherapy Stimulation （CES） in treatment for depression patients. Methods： Eighty depression patients were randomly divided into the groups of CES and control equally. The two groups were given antidepressants, and the CES group was received additional CES treatment. All the treatment lasted for 6 weeks. Disease Severity was assessed by Hamilton depression rating scale （HAMD） and Hamilton anxiety scale （HAMA）. The cognitive function was assessed by Wisconsin Card Sorting Test （WCST）. The safety was evaluated with Treatment Emergent Symptom Scale （TESS）. Results： There were 38 cases in the CES group and 37 cases in the control group who had completed 6 study. After the treatment, the HAMD and HAMA scores in the 2 groups were significantly lower than those before the treatment（P〈0.01）. At the sixth week, the assisted efficiency and curative rates between the two groups showed no significant difference （P〉0.05）. At the fourth week, the efficiency in the CES group was significantly higher than that in the control group （P〈0.05）. The comparison of the adverse events between the two group revealed no difference （P〉 0.05）. Conclusion： CES in adjuvant treatment of depression is safe and effective.
出处
《神经损伤与功能重建》
2014年第4期317-319,341,共4页
Neural Injury and Functional Reconstruction
基金
江苏省常熟市卫生局科技计划项目(csws201210)
关键词
经颅微电流刺激疗法
抑郁症
疗效
安全性
cranial electrotherapy stimulation
depression
curative effect
safety
