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抗N-甲基-D-天冬氨酸受体脑炎研究现状 被引量：7

Update in the research of anti-N-methyl-D-aspartate receptor encephalitis
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摘要 2007年,美国宾夕法尼亚大学教授Dalmau等[1]提出了“抗N-甲基-D-天冬氨酸受体（NMDAR）脑炎”的概念,系由机体针对NMDAR产生特异性IgG抗体导致的一种边缘性脑炎（LE）.此后,对该类型脑炎的研究如雨后春笋般成为临床最常见、最受重视的自身免疫性脑炎.
作者 王佳伟
机构地区 首都医科大学附属北京同仁医院神经内科
出处 《中国现代神经疾病杂志》 CAS 2014年第8期658-659,共2页 Chinese Journal of Contemporary Neurology and Neurosurgery
基金 国家自然科学基金资助项目(项目编号:81301029) 北京市卫生系统高层次卫生技术人才培养计划(项目编号:2011-3-004)~~
关键词 受体 N-甲基-D-天冬氨酸 脑炎 综述 Receptors, N-methyl-D-aspartate Encephalitis Review
分类号 R512.3 [医药卫生—内科学]
  • 相关文献

参考文献17

  • 1Dalmau J,Tiizün E,Wu HY,Masjuan J,Rossi JE,Voloschin A,Baehring JM,Shimazaki H,Koide R,King D,Mason W,Sansiug LH,Dichter MA,Rosenfeld MR,Lynch DR.Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma.Ann Neurol,2007,61:25-36.
  • 2Dalmau J,Lancaster E,Martinez-Hernandez E,Rosenfeld MR,Balice-Gordon R.Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis.Lancet Neurol,2011,10:63-74.
  • 3Dalmau J,Gleichman AJ,Hughes EG,Rossi JE,Peng X,Lai M,Dessain SK,Rosenfeld MR,Balice-Gordon R,Lynch DR.Anti-NMDA-receptor encephalitis:case series and analysis of the effects of antibodies.Lancet Neurol,2008,7:1091-1098.
  • 4Rosenfeld MR,Titulaer MJ,Dalmau J.Paraneoplastic syndromes and autoimmune encephalitis:five new things.Neurol Clin Pract,2012,2:215-223.
  • 5Viaccoz A,Desestret V,Ducray F,Picard G,Cavillon G,Rogemond V,Antoine JC,Delattre JY,Honnorat J.Clinical specificities of adult male patients with NMDA receptor antibodies encephalitis.Neurology,2014,82:556-563.
  • 6Titulaer MJ,Dalmau J.Seizures as first symptom of anti-NMDAreceptor encephalitis are more common in men.Neurology,2014,82:550-551.
  • 7Titulaer MJ,McCracken L,Gabilondo I,Iizuka T,Kawachi I,Bataller L,Torrents A,Rosenfeld MR,Balice-Gordon R,Graus F,Dalmau J.Late-onset anti-NMDA receptor encephalitis.Neurology,2013,81:1058-1063.
  • 8Gresa-Arribas N,Titulaer MJ,Torrents A,Aguilar E,McCracken L,Leypoldt F,Gleichman AJ,Balice-Gordon R,Rosenfeld MR,Lynch D,Graus F,Dalmau J.Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis:a retrospective study.Lancet Neurol,2014,13:167-177.
  • 9Mangler M,Trebesch de Perez I,Teegen B,Stocker W,Prüss H,Meisel A,Schneider A,Vasiljeva J,Speiser D.Seroprevalence of anti-N-methyl-D-aspartate receptor antibodies in women with ovarian teratoma.J Neurol,2013,260:2831-2835.
  • 10Prüss H,Finke C,Holtje M,Hofmann J,Klingbeil C,Probst C,Borowski K,Ahnert-Hilger G,Harms L,Schwab JM,Ploner CJ,Komorowski L,Stoecker W,Dalmau J,Wandinger KP.N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis.Ann Neurol,2012,72:902-911.

二级参考文献40

  • 1Dalmau J, Tfizfin E, Wu HY, et al. Paraneoplastic anti-N- Methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol, 2007, 61: 25-36.
  • 2Vitaliani R, Mason W, Anees B, et al. ParaneopIastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma. Ann Neurol, 2005, 58: 594-604.
  • 3Dalmau J, Gleichman AJ. Anti-NMDA-reeeptor encephalitis:case series and analysis of the effects of antibodies. Lancet Neurol, 2008, 7 : 1091-1098.
  • 4Poloni C, Korff CM, Ricotti V, et al. Severe childhood encephalopathy with dyskinesia and prolonged cognitive disturbances: evidence for anti-N-methyl-D-aspartate receptor encephalitis. Dev Med Child Neurol, 2010, 52: 78-82.
  • 5Hung TY, Foo NH, Lai MC. Anti-N-methyl-d-aspartate receptor encephalitis. Pediatr Neonatol, 2011, 52: 361-364.
  • 6Florance RN, Dalmau J. Update on anti-N-methyl-D-aspartate receptor encephalitis in children and adolescents. Curr Opin Pediatr, 2010, 22: 739-744.
  • 7Schimmel M, Bien CG, Vincent A, et al. Successful treatment of anti-N-methyl-D-aspartate receptor encephalitis presenting with catatonia. Arch Dis Child,2009, 94:314-316.
  • 8Dalmau J, Lancaster E, Martinez HE, et al. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neural, 2011, 10:63-74.
  • 9Florance NR, Davis RL, Lain C, et al. Anti-N-methyl-D- aspartate receptor (NMDAR) encephalitis in children and adolescents. Ann Neural, 2009, 66 : 11-18.
  • 10Iizuka T, Yoshii S, Kan S, et al. Reversible brain atrophy in anti- NMDA receptor encephalitis: a long-term observational study. J Neurol, 2010, 257 : 1686-1691.

共引文献68

同被引文献46

  • 1Broca P.Anatomie comparée des circonvolutions cérébrales:le grand lobe limbique et la scissure limbique dans la série des mammiféres.Rev Antrhrop,1878,1:385-498.
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  • 3Ramanathan S,Mohammad SS,Brilot F,Dale RC.Autoimmune encephalitis:recent updates and emerging challenges.J Clin Neurosci,2014,21:722-730.
  • 4Xu CL,Liu L,Zhao WQ,Li JM,Wang RJ,Wang SH,Wang DX,Liu MY,Qiao SS,Wang JW.Anti-N-methyl-D-aspartate receptor encephalitis with serum anti-thyroid antibodies and IgM antibodies against Epstein-Barr virus viral capsid antigen:a case report and one year follow-up.BMC Neurol,2011,11:149.
  • 5Vincent A.Autoimmune encephalitis.J Neurol Neurosurg Psychiatry,2014,85:E3.
  • 6Kayser M S, Dalmau J. Anti-NMDA receptor encephalitis in psychiatry [ J ]. CUlT Psychiatry Rev,2011,7 ( 3 ) : 189-193.
  • 7Titulaer M J, Mccracken L, Gabilondo I, et al. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study [ J ]. Lancet Neurol,2013,12(2) :157-165.
  • 8Dalmau J, Gleichman A J, Hughes E G, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies[ J]. Lancet Neuro1,2008,7 ( 12 ) : 1091-1098.
  • 9Hansen H C, Klingbeil C, Dalmau J, et al. Persistent intrathecal antibody synthesis 15 years after recovering from anti-N-methyl-D- aspartate receptor encephalitis [ J ]. JAMA Neurol, 2013,70 ( 1 ) : 117- 119.
  • 10Miya K, Takahashi Y, Moil H. Anti-NMDAR autoimmurte encephalitis [ J]. Brain Dev ,2014,36 ( 8 ) :645-652.

引证文献7

二级引证文献35

中国现代神经疾病杂志
2014年 第8期

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