摘要
目的通过观察急性胰腺炎(acute pancreatitis,AP)患者的血浆胰岛素、C肽、血糖及粪弹性蛋白酶的变化,以研究胰腺内外分泌功能在病程中的变化及其临床意义。方法放免法测定52例急性胰腺炎患者(其中重型30例,轻型22例)入院第1、7、14天和发病后3个月、12个月血浆胰岛素、C肽、血糖及粪弹性蛋白酶水平的变化,与20例健康者(对照组)比较,判断AP内外分泌功能的变化。结果重型胰腺炎C肽及胰岛素水平明显低于对照组(P<0.05)。血糖变化在重型胰腺炎组与对照组有明显差异(第1天除外)(P<0.05),粪弹性蛋白酶第1天增高,7 d后下降(P<0.05),重症更明显。结论 AP时,胰腺内外分泌功能均受到损害,在临床中监测、治疗和随访AP患者,注意内外泌功能的变化是有利的。
Objective To investigate the changes and clinical significance of endocrine and exocrine functions of patients with acute pancreatitis by observing the changes of plasma insulin,C-peptide,glucose and fecal elastase.Methods The changes of endocrine and exocrine functions were measured to assay insulin,C-peptide,glucose and fecal elastase by radioimmunoassay in 52 cases of acute pancreatitis in day 1,7,14 after admission,3 months and 12 months after morbidity,compared with 20 cases of healthy volunteers （control group）.Results The levels of plasma insulin and C-peptide in severe pancreatitis patients were significant lower than those in the control group （P ＜ 0.05）.The changes of blood glucose were significant different between severe pancreatitis group and the control group （except day 1） （P ＜ 0.05）,fecal elastase was increased in the first day,and decreased after 7 d （P ＜ 0.05）.Conclusion Endocrine and exocrine dysfunctions were injured when acute pancreatitis occurved.When endocrine dysfunction,exogenous insulin complementary and glucose monitoring should be noticed,but also trypsin complementary in exocrine dysfunction.
出处
《胃肠病学和肝病学杂志》
CAS
2014年第7期834-836,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
急性胰腺炎
内分泌功能
外分泌功能
C肽
胰岛素
粪弹性蛋白酶
Acute pancreatitis
Endocrine function
Exocrine function
C-peptide
Plasma insulin
Fecal elastase
