摘要
目的了解住院老年患者感染大肠埃希菌的临床分布及其产超广谱β-内酰胺酶(ESBLs)阳性菌株和耐药性变化。方法采用病原学标本分离鉴定和药敏试验方法,对某医院住院患者送检标本检测结果进行回顾性调查。结果从该医院住院患者送检标本中共检出大肠埃希菌692株,尿液、痰液和脓液标本检出率分居前三位,构成比分别为39.5%、32.2%和20.7%。送检标本最多的分别是普外科、泌尿外科和重症监护病房,构成比依次为22.3%、18.9%和16.5%。医院感染大肠埃希菌中产ESBLs菌株呈现增加趋势,其构成比从2008年的28.6%升至2012年的61.2%。ESBLs阳性株对氨苄西林等14种药物的耐药率均高于ESBLs阴性株,且有逐年增加趋势。结论该医院住院老年患者感染的大肠埃希菌中产ESBLs菌株检出率和耐药率均呈现逐年上升趋势,主要防控措施是加强耐药性监测和药敏试验,为临床合理用药提供参考。
Objective To know the distribution of Escherichia coli infection and the change of extended spectrum of β - lactamase （ESBLs） - positive strains and drug resistance of the hospitalized senile patients patients. Methods Pathogens identification and drug susceptibility test were used to investigate the clinical isolates samples from the hospital senile inpatients. Results 692 strains of E. coli were isolated, and the top three were urine 39. 5%, sputum 32. 2% and pus 20.7%. Most were from departments of General Surgery 22. 3%, Urology 18.9%, and ICU 16. 5%. E. coli strains of producing ESBLs showed an increasing trend from 28.6% in 2008 to 61.2% in 2012. The resistant rates of ESBLs positive strains to ampicillin and other 14 kinds of drugs were higher than ESBLs - negative, and showed an upward trend year by year. Conclusion The rate of producing ESBLs strains detection and resistance of E. coli isolated from senile patients showed an increasing trend, the main control measures is to strengthen surveillance of antimicrobial resistance and susceptibility testing, so as to provide reference for clinical rational drug use.
出处
《中国消毒学杂志》
CAS
北大核心
2014年第7期722-725,共4页
Chinese Journal of Disinfection
关键词
老年患者
大肠埃希菌
超广谱Β-内酰胺酶
耐药性
senile patients
Escherichia coli
extended - spectrum β- lactamase
drug resistance
