摘要
目的探讨药学干预对抗生素用药的影响。方法选择2010年和2012年齐河县人民医院抗生素的使用情况，并且随机选取2010年和2012年各360例住院患者的资料。结果2012年齐河县人民医院住院部和门诊部抗生素使用率均较2010年有明显下降（P〈0．05）。2012年抗生素销售额、抗生素占药品销售额比例、抗生素总体药物日均费用（DDc）比2010年有明显降低（P〈0．05）。2010年排名前10的抗生素中有头孢吡肟、亚胺培南和氨曲南，2012年均退出前10位。2012年使用频度最高的为头孢孟多和阿奇霉素。2012年抗生素使用的用药指征、药物选择、首次用药时间、术后给药的合理性均优于2010年（P〈0．05）。2012年患者预防性抗生素的使用中第1代头孢菌素和克林霉素比例明显升高（P均〈0．05），第2、3代头孢菌素和大环内酯类比例明显降低（P均〈0．05）。结论药学干预后抗生素使用更加合理。
Objective To study the effect of pharmaceutical otis The patients using antibiotics in Qihe people＇ s hospital in 2010 hospitalized patients 2010 and 2012 were randomly enrolled. Results intervention on antibiotics. Meth- and 2012 were selected. Each 360 The antibiotic utilization of hospital inpatient and outpatient in 2012 decreased significantly than that in 2010 （ P 〈 0. 05 ）. The sales of antibiotics, antibiotic drug sales accounted for the proportion and antibiotic medication daily fee （DDc） in 2012 were significantly lower than those in 2010 （P 〈0. 05 ）. Cefepime, imipenem and aztreonam were in top 10 antibiotics in 2010. In 2012, azithromycin and cefamandole were the highest frequency of use. The antibiotic medication indications, drug selection, the first medication time, postoperative administration of rationality in 2012 were better than those in 2010 （P 〈 0. 05 ）. In 2012, the use of prophylactic antibiotics in patients with firstgeneration cephalosporins and clindamycin was significantly increased （P 〈 0. 05 ）, the second and thirdgeneration cephalosporins and macrolides was significantly lowered （P 〈 0. 05 ）. Conclusions Pharmaceutical intervention made more rational use of antibiotics.
出处
《中国实用医刊》
2014年第15期51-53,共3页
Chinese Journal of Practical Medicine
关键词
抗生素
药学干预
Antibiotics
Pharmaceutical intervention
