摘要
目的 探讨广州市城乡居民血脂和血糖长期变化趋势.方法 1983和1984年以整群随机抽样的方法,在广州造船厂及广州市番禺区大石镇（现大石街及洛浦街）抽取调查人群,年龄35～ 65岁,男女性各半,收集血脂和血糖基线资料,并分别于1998、2004、2007或2011年对相同地区人群进行复查.采用世界卫生组织标准化人口进行现患率的标准化.结果 （1）各种危险因素的年龄调整均数水平和现患率在城乡人群和男女性人群之间差异有统计学意义（P ＜0.01或0.05）;（2）总胆固醇（TC）、甘油三酯（TG）、血糖和高密度脂蛋白胆固醇（HDL-C）水平在城乡人群中自2004年后升高缓慢或者有所下降;（3）多种危险因素包括高TG、低HDL-C、血脂异常、空腹血糖升高和糖尿病的标化现患率在2004年前持续上升,2004年后升高缓慢甚至下降,而高TC标化率处于较高水平.结论 2004年后,除高TC外,广州市35～ 65岁城乡居民高TG、低HDL-C、血脂异常、空腹血糖升高和糖尿病的现患率从高水平开始下降,危险因素得到控制并有改善趋势,必须进一步加强群体危险因素的控制.
Objective To observe the long term trends of blood lipid and glucose change in Guangzhou urban and rural natural population.Methods We cross-sectionally studied individuals 35 to 65 years of age （50% male） from People＇ Republic of China-United States cardiovascular and cardiopulmonary epidemiology research study using random sampling design in Guangzhou Shipyard and Panyu Dashi Town （Dashi Street and Luopu Street now） in 1983 and 1984 （n =4 548）,1998 （n =1 593）,2004 （n =2 095） and 2011 （n =1 692）.Prevalence of dyslipidemia and pathoglycemia were standardized to the WHO world standard population.Blood lipid and glucose levels were compared in this cohort during the 28 years.Results （1） The age adjusted mean average levels of blood lipid and glucose and the standardized prevalence rate of dyslipidemia and increased blood glucose as well as cardiovascular risk factors were significantly higher in the urban than in the rural residents and higher in male than in female participants （P 〈 0.01 or 0.05）.（2） The age adjusted mean level of blood total cholesterol （TC）,triglyceride （TG）,glucose and high density lipoprotein cholesterol （HDL-C） increased from 1983/1984 to 2004 year in both urban and rural residents,and trended to be stable or decreased thereafter.（3） Standardized prevalence of multiple cardiovascular risk factors,such as high blood TG,low HDL-C,blood lipid disorder,fasting blood glucose level and diabetes,steadily increased from 1983/1984 to 2004 and this increasing trend was slowed or reversed thereafter,except the prevalence rate of high blood TC.Conclusions Except for high blood TC,the prevalence of multiple cardiovascular risk factors,such as high blood TG,low HDL-C,higher fasting blood glucose and diabetes,tended to be under control after 2004 in this cohort.Further efforts are warranted to strengthen this positive trend in the natural population.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2014年第6期515-519,共5页
Chinese Journal of Cardiology
基金
基金项目：国家“八五”计划（85-915-01-01）
国家“九五”计划（96-906-02-01）
国家“十五”计划（2001BA703801）
科技攻关项目及卫生行业科研专项（2009-02-001）
关键词
血脂异常
血糖
Dyslipidemias
Blood glucose
