摘要
目的 :研究乳腺癌组织中细胞外基质金属蛋白酶 9(MMP 9)和组织基质金属蛋白酶抑制剂 2 (TIMP 2 )的表达及其与淋巴转移和预后的相关性。方法 :通过免疫组织化学的方法检测 10 9例乳腺癌组织中MMP 9和TIMP 2表达的情况。结果 :MMP 9和TIMP 2在人乳腺癌中表达的阳性率分别为 6 6 97%和 30 2 7% ;MMP 9的表达与组织学分级、淋巴结转移呈正相关 (P <0 0 1) ,与术后生存率呈负相关 ,而TIMP 2的表达则相反。结论 :MMP 9和TIMP 2的表达与乳腺癌淋巴结转移与预后密切相关 。
Purpose To investigate the expression of MMP-9 and TIMP-2 in breast carcinoma and its metastasis and prognosis. Methods One hundred and nine cases of breast carcinoma were studied by S-P immunohistological staining with MMP-9 and TIMP-2. Results The expression rate of MMP-9 were 66.97% and 30.27%. The expression of MMP-9 was positively correlated to histological grade and lymph node metastasis and negatively to survival time. The expression of TIMP-2 was negatively correlated to lymph node metastasis and positively to survival time. Conclusion The expression of MMP-9 and TIMP-2 are closely correlated to histological grade and lymph node metastasis and its survival time in breast carcinoma which may serve as parameter for determing tumor biological behavior and prognosis.
出处
《临床与实验病理学杂志》
CAS
CSCD
2002年第3期268-270,共3页
Chinese Journal of Clinical and Experimental Pathology
