摘要
目的 探讨体质指数水平与冠心病事件和脑卒中发病的关系。方法 1982～ 1985年在我国不同地区的 10组人群中 (年龄 35～ 5 9岁 )进行心血管病危险因素调查 ,对其中无脑卒中、无心肌梗死及无恶性肿瘤史的研究对象随访至 1999～ 2 0 0 0年 ,登记并核实冠心病事件、脑卒中事件的发生情况以及各种原因的死亡。结果 对共计 2 4 90 0人 ,平均 15 2年的随访中 ,共发生冠心病事件 2 5 3例 ,脑卒中事件 797例 ,其中缺血性脑卒中 4 5 3例 ,出血性脑卒中 311例。用Cox比例风险回归模型(调整年龄、性别、收缩压、血清总胆固醇水平、吸烟和饮酒情况 )估计低体重组 (BMI<18 5 )、正常体重组 (BMI为 18 5～ 2 3 9)、超重组 (BMI为 2 4～ 2 7 9)和肥胖组 (BMI≥ 2 8)发生冠心病事件的相对危险分别为 0 70、1 0、1 33和 1 74 ,缺血性脑卒中的相对危险分别为 0 5 6、1 0、2 0 3和 1 98。与非超重者相比 ,超重和肥胖者冠心病事件和缺血性脑卒中事件的归因危险度百分比分别为 32 0 %和 5 3 3% ,人群归因危险度百分比分别为 7 3%和 16 1%。结论 体质指数与冠心病事件、缺血性脑卒中的发病危险呈明显的正关联。控制体重、降低超重和肥胖率应是预防冠心病和缺血性脑卒中的重要措施。
Objective To assess the relationship between body mass index (BMI) and incidence of coronary heart disease and stroke Methods CVD risk factors were surveyed in 1982～1885 for more than 30 thousand participants aged 35 ～59 from 10 Chinese populations Follow up was carried out to 1999～2000 for the participants without known myocardial infarction, stroke and cancer CHD events (including acute myocardial infarction, CHD death and coronary sudden death), stroke events and all causes of death were documented Results Out of the whole cohort of 30 560 participants, 24 900 with complete data were available for the present analysis Among those, 253 CHD events, 797 stroke events, including 453 ischemic stroke and 311 hemorrhagic stroke occurred during the follow up of 15 2 years on average Cox proportional hazards models adjusted for age, gender, SBP, TC, smoking and alcohol drinking were used to estimate the relative risks of CHD and stroke events of different BMI groups which were defined according to the strata of BMI for Chinese The participants with increased BMI significantly increased the risk of CHD and ischemic stroke and the relative risks in low weight (BMI<18 5), normal weight (BMI from 18 5 to 23 9), overweight (BMI from 24 to 27 9) and obesity groups (BMI≥28) were 0 70 (95%CI:0 44～1 14), 1 0, 1 33 (95%CI:0 97～1 82) and 1 74 (95%CI:1 08～2 83) for CHD events, and 0 56 (95%CI:0 36～0 86), 1 0, 2 03 (95%CI:1 65～2 52) and 1 98 (95%CI:1 40～2 79) for ischemic stroke, respectively There was not a significantly relationship between BMI and hemorrhagic stroke Compared with the non overweight group(BMI<24), attributable risk percent (AP%) and population attributable risk percent (PAP%) were 32 0% and 7 3% for CHD events, 53 3% and 16 1% for ischemic stroke events among overweight obesity group(BMI≥24) , respectively Conclusion The levels of BMI were significantly positively related to CHD and ischemic stroke events It may be an effective way to reduce overweight and obesity for preventing from CHD and stroke event
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2002年第7期430-433,共4页
Chinese Journal of Cardiology
基金
国家"九五"科技攻关课题 (专题合同号 :96 90 6 0 2 0 1)
卫生部疾病控制司慢性非传染性疾病预防与控制专题研究 (课题号 :3 -3课题 )
