摘要
目的 探讨不同体重指数 (BMI)水平与总死亡及不同死因死亡的关系。方法 1982～1985年在我国不同地区的 10组人群中 (年龄 35～ 5 9岁 )进行心血管病危险因素调查 ,并对研究对象中无脑卒中、无心肌梗死及无恶性肿瘤史的 30 5 6 0人 (男性 15 72 3人 ,女性 14837人 )随访至 1999～2 0 0 0年 ,登记各种死亡的发生情况。结果 在平均 15 .2年的随访中 ,共死亡 32 12例 ,其中冠心病和脑卒中共死亡 6 76例 ,恶性肿瘤死亡 12 81例 ,其他原因死亡 12 5 5例。用Cox比例风险回归模型 (调整年龄、性别 )估计低BMI组 (BMI <18.5 )、正常BMI组 (BMI为 18.5～ 2 3.9)、超重组 (BMI为 2 4～2 7.9)和肥胖组 (BMI≥ 2 8)总死亡的相对危险分别为 1.2 1,1.0 0 ,0 .91,1.12 ,呈“U”形关系 ,当同时剔除前 5年死亡病例及吸烟者后 ,低BMI组死亡的相对危险降低 ,而肥胖组增加 ,正常BMI组的相对危险最小。随着BMI水平的上升 ,冠心病和脑卒中死亡的相对危险增加 ,恶性肿瘤死亡的相对危险降低 ,其他原因死亡的相对危险与BMI水平呈“U”形关系 ,当剔除早期死亡病例及吸烟者后 ,这些趋势依然存在。结论 BMI在正常范围内 ,总死亡的相对危险较低 ,且冠心病和脑卒中死亡、恶性肿瘤死亡及其他原因死亡的综合风险也处于相对较低水平 ,
Objective To assess the relationship between body mass index (BMI, weight in kilograms divided by the square of height in meters) and both all-causes mortality and mortality from specific cause. Methods Cardiovascular disease (CVD) risk factors were studied in 1982-1985 on more than 30 thousands participants aged 35-59 from 10 Chinese populations. 30 560 participants ( 15 723 for men, 148 837 for women) without known myocardial infraction, stroke or cancer was followed from 1999 to 2000. All-causes of death were documented. Results Three thousand two hundred and twelve death cases occurred during follow-up of average 15.2 years, including 676 CVD (coronary heart disease and stroke) deaths, 1 281 cancer deaths and 1 255 deaths for other reasons. Cox proportional hazards model adjusting age and gender showed that the relative risks of all causes of death in groups of low BMI (BMI< 18.5), normal BMI (BMI from 18.5 to 23.9), overweight (BMI from 24 to 27.9) and obesity (BMI≥28) which were defined according to the strata of BMI for Chinese were 1.21 (95%CI: 1.10- 1.33), 1.00, 0.91 (95%CI: 0.82- 1.01) and 1.12 (95%CI: 0.93- 1.37), respectively ('U' shaped relation). The relative risk of low BMI group (RR= 1.01, 95%CI: 0.84- 1.21) was not significant different and the relative risk of obesity significantly increased (RR= 1.36, 95%CI: 1.04- 1.80) while the lowest relative risk was in normal BMI group. The relative risks increased for CVD death, but decreased for cancer death with increased levels of BMI and a 'U' shaped relationship was found between BMI groups and mortality for other reasons, which remained after excluding the early death and smokers. Conclusion BMI in normal level was not only related to low risk of all causes of death, but also with relative low risk of CVD, cancer and other deaths. Data were important to public health.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2002年第1期24-27,共4页
Chinese Journal of Epidemiology
基金
国家"九五"科技攻关资助项目 ( 96 90 6 0 2 0 1)
关键词
体重指数
死亡率
相对危险度
心血管病
Body mass index(BMI)
Mortality
Prospective study
Relative risk
