摘要
本实验在离体大鼠心脏灌流模型上,观察到10^(-9)mol/L内皮素灌流引起心肌挛缩,心功能降低,冠脉灌流量减少,以及心肌Ca^(2+)聚积,Mg^(2+)丧失等表现。灌流液含低镁(0.12mmol/L)时内皮素对心脏的上述作用显著增强,而在含高镁(4.8mmol/L)时明显减弱。Mg^(2+)影响内皮素对心脏作用的机制可能与其抑制心肌Ca^(2+)内流有关。实验结果提示避免缺镁,适当补充Mg^(2+)对于防治伴有循环内皮素水平增加的疾病或病理过程中的心脏损伤可能具有临床意义。
This work observed on isolated perfused rat hearts, that 10^(-9)mol/L endothelin (ET) induced myocardial contracture, decrease of heart function and coronary flow, intramyocardial Ca^(2+) accumulation and Mg^(2+) loss and etc. These cardiac action of ET were obviously more prominent when Mg^(2+) in the perfusion fluid was lowered to 0.12 mmol/L, and were significantly alIeviated when Mg^(2+) content was increased to 4.8mmol/L (normal plasma Mg^(2+) content is about 1.2 mmol/L). The mechanism of the Mg^(2+) effect on the cardiac action of ET may be related to its inhibition of Ca^(2+) influx into the myocytes. These results suggested that without magnesium defficiency, suitable replenishment of Mg^(2+) probably have practical clinical significance in the prevention and therapy of myocardial injury occurred during diseases with elevated circulatory ET level.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1991年第5期466-469,共4页
Chinese Journal of Pathophysiology
基金
国家科委资助"七五"攻关项目
关键词
心脏
内皮素
镁
灌流
Endothelin
Magnesium
Heart
Perfusion
