摘要
本实验表明犬感染性休克时与氧自由基有关参数之间的变化存在一定关系。血浆丙二醛(MDA)升高与血中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性降低和血浆β-葡萄糖醛酸酶(β-GC)、血浆游离血红蛋白(PHb)升高呈正相关;β-GC升高与SOD,GSH-Px活性降低正相关,SOD活性降低与PHb升高正相关,存活时间与MDA,β-GC升高及SOD活性降低负相关(P<0.05或P<0.01)。结果提示氧自由基在感染性休克发病过程中起着重要作用,MDA、β-GC、SOD改变可作为判断感染性休克严重程度的指标。
This study showed that there were significant relations among the parameters associated with oxygen free radical (OFR) in the blood of dogs with septic shock. There were positive correlations between the increase of malondialdehyde (MDA) and the decrease of activities in both superoxide dismutase (SOD) and glutathion peroxidase (GSH-Px), the increase of β-glucuronidase (β-GC) activity, the increase of plasma free hemoglobirn(PHb) separately. The increase of β-GC and the decrease of activities in both SOD and GSH-Px also exhibited positive correlation and so did the decrease of SOD activity and the increase of PHb. The correlation between the survival time and both of the increase in degree of MDA and β-GC and the decrease in degree of SOD activity was negative These correlations mentioned above were statistically significant (P<0.05 or<0.01). These results suggest OFR plays an important role in pathogenesis of septic shock, and MDA, β-GC and SOD might serve as indices to evaluate the the severity of septic shock.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1991年第3期286-289,共4页
Chinese Journal of Pathophysiology
关键词
休克
脓毒性
氧自由基
丙二醛
free radicals
Shock, septic
Malondialdehzde
Glucuronidase
Superoxide dismutase
