摘要
目的 探讨心肌声学造影技术评价不同频率快速心房起搏预适应减小缺血再灌注后心肌梗死范围的作用。方法 2 0条健康成年杂种犬随机分为三组 :A组 6条 ,为非缺血性快速心房起搏预适应组 ;B组 7条 ,为缺血性快速心房起搏预适应组 ;C组 7条 ,为对照组。A、B两组完成 3个回合的快速起搏预适应后 ,与C组一道结扎阻断左前降支冠脉血流 60min ,随后再灌注 60min。在持续缺血和再灌注阶段行心肌声学造影检查 (MCE) ,比较各组缺血再灌注后心肌梗死的面积以及心肌坏死区面积与危险区面积之比 (NA/RA) ,并与氯化三苯四氮唑 (TTC)心肌组织染色结果对照。结果 A、B组NA/RA值均小于C组 ,且B组又小于A组 (P <0 .0 5 )。MCE结果和TTC染色结果呈高度正相关。结论 缺血性和非缺血性快速心房起搏预适应对犬心肌缺血再灌注损伤均有保护作用 ,缺血性快速起搏预适应的保护效力大于非缺血性起搏预适应。
Objective To investigate the protective effect of preconditioning induced by rapid atrial pacing in reducing infarct size using myocardial contrast echocardiography (MCE).Methods Twenty anaesthetized dogs were randomly divided into three groups as follows: nonischemic pacing preconditioned group(group A), ischemic pacing preconditioned group(group B) and control group(group C). In control group,the anterior descending coronary artery was occluded for 60 minutes, subsequently, reperfused for 60 minutes. In preconditioned groups of dogs a similar protocol was followed, but three periods of rapid atrial pacing (at various rate between A and B group), 5 minutes in duration each, with 5 minutes of intervening periods at rest heart rate, were induced previous to the coronary occlusion. Results During ischemia and reperfusion the risk area (RA) and necrotic region (NA) were depicted respectively by MCE. Atrial pacing preconditioning significantly reduced the infarct size (NA:RA) in canine hearts compared to control, a further reduction in group B with respect to group A.Conclusions The rapid atrial pacing preconditions the myocardium against ischemia reperfusion injury. The ischemic pacing preconditioning is more effective in limiting infarct size than the preconditioning induced by nonischemic pacing.
出处
《中华超声影像学杂志》
CSCD
2002年第7期419-423,共5页
Chinese Journal of Ultrasonography
关键词
超声心动描记术
造影剂
快速心房起搏
预适应
心肌再灌注
心肌梗塞
Echocardiography
Contrast media
Rapid atrial pacing
Preconditioning
Myocardial reperfusion
Myocardial infarct
