摘要
呕吐是多种疾病常见的临床症状。有研究证实:呕吐有相关的异常胃肠电活动。临床与实验表明,针刺对消化系疾患有良好的疗效,针刺对胃肠电有双向调节作用。针刺有无镇吐效应?针刺镇吐作用机理如何?乃是本研究目的。
Acute experiments were performed on 20 guinea pigs. The animals were divided at random into four groups of five each. the nonacupuncture group for control and three electroacupunctured groups (EA-Ⅰ, EA-Ⅱ, EA-Ⅲ). Four pairs of platinum-wire electrodes were implanted under serosa of the antrum and corpus, duodenum, jijunum. The gastroenteric electric activity (GEA) was recorded in conscious and fasting state. Needling was applied at position lcm below the knee, corresponding to Zusanli. The peripheral vomitng model was established by infusion of CuSo_4 into the stomach. Observation was made with regard to latency of vomiting induced by infusion of CuSo_4, duration of the symptom, number of fits in the pirst five msnutes after the attack began, and the variation of amplitude and frequency of GEA. The results were as follows: (1) The GEA of normal guinea pigs showed regular cyclic changes. After latency of 3.7 seconds following the infusion, symptom of vomiting began appear. The GEA returned to normal after latency of 60 minutes. (2) During vomiting, the GEA was characterized by a series of spikes whichwere seen more obseously in the antrum and corpus; during serious fits of vomiting, duodenum and jijunum were involved. The GEA showkd disordered and quicker rhythm with higher amplitude and frequency. (3) EA could not affect the latency of the peripheral vomiting, but It could shorten the duration of the symptom. Results of group EA-Ⅱ(p<0.001) showed EA could reduce the number of fits during the first five minutes; results og group EA-Ⅰ(p<0.01) showed that EA could lower the amplitude and frequency of the GEA (p<0.05) that rose during vomiting. This indicates that EA has certain regulating effect on the GEA of peripheral vomiting. The mechanism of EA on anti-emesis was primaryly discused.
出处
《针刺研究》
CAS
CSCD
1991年第1期69-72,共4页
Acupuncture Research
