摘要
目的 探讨GSTM1基因多态性与膀胱癌遗传易感性的关系。 方法 采用PCR技术 ,以病例 对照研究方法 ,对 6 9例膀胱癌患者和 88例健康对照者的GSTM 1基因型进行检测。 结果 膀胱癌患者GSTM1空白基因型频率为 5 8% ,对照组为 4 1% ,两组比较差别有显著性意义 (χ2 =4 .5 1,P <0 .0 5 ) ,OR值为 2 .0 (95 %CI =1.0 5～ 3.79)。吸烟者中 ,患者组GSTM1空白基因型频率为71% ,对照组为 2 4 % ,两组比较差别有显著性意义 (χ2 =2 2 .6 ,P <0 .0 1) ,OR值为 8.3(95 %CI =3.34～ 2 0 .6 5 )。以GSTM1非空白型 /不吸烟者为参照 ,GSTM1空白型 /吸烟者的OR值为 4 .6 4 (95 %CI=1.86～ 11.37,χ2 =11.6 3,P <0 .0 1) ,差别有显著性意义。 结论 GSTM 1基因多态性与膀胱癌易感性有关 。
Objective To study the correlation between GSTM1 genetic polymorphism and bladder cancer susceptibility. Methods In a case control study, the GSTM1 genotype was assessed by a PCR based method. 69 patients with transitional cell carcinoma of the bladder and 88 controls matched for age and sex were studied. Results The frequency of GSTM1 null genotype among the bladder cancer patients was 58% compared with 41% among controls(OR=2.0, 95%CI=1.05～ 3.79 ,χ 2=4.51, P <0.05). A significantly higher incidence of GSTM1 null genotype (χ 2=22.6, P <0.01) was found in smokers with bladder cancer as compared to the controls (71% vs 24%,OR=8.3,95%CI=3.34～20.65).As compared to when the GSTM1 +/+/non smokers and GSTM1 null/smokers had a significantly increased risk of bladder cancer (OR=4.64, 95%CI=1.86～11.37). Conclusions The results suggested that GSTM1 polymorphisms are notably associated with bladder cancer susceptibility.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2002年第6期344-346,共3页
Chinese Journal of Urology
