摘要
目的:探讨99mTc-MIBI肺肿瘤摄取与P-糖蛋白(Pgp)在肺癌多药耐药(MDR)表达之间的关系,以及99mTc-MIBI肺肿瘤显像在预测抗肿瘤药物化疗敏感性的价值。方法:回顾性分析38例肺癌的99mTc-MIBI肺肿瘤图像,计算T?Ne、T?Nd和RI,并根据Pgp的表达与否(阳性和阴性)及化疗方案的有效性与否(好转和加重)分组,对各组数据进行相关性分析。结果:32例患者的肿瘤组织进行了免疫组化分析,其中9例Pgp表达阳性(阳性组),23例表达阴性(阴性组),两组的T?Ne、T?Nd和RI值未见统计学差异。有完整化疗数据的20例中,病情好转与加重分别有10例,统计显示两组仅在T?Ne间有差异(P<0.05),分别是1.76±0.50和1.28±0.51。结论:99mTc-MIBI肺肿瘤显像可以预测肺癌对化疗的敏感性,但是确定其肺癌化疗敏感性的机制和标准化的方法,还有待于进一步的研究。
Objective:To investigate the efficiency of 99m Tc-MIBI chest imaging in predicting the expression of multidrug resistance-mediated P-glycoprotein and the chemotherapeutical response to anticancer drugs for lung cancer.Methods:99m Tc-MIBI chest images in38patients with lung cancer were retrospectively analyzed and three semiquantitative parameters,T?Ne ?T?Nd(tumor-to-normal lung ratios in early and delayed image respectively)and RI(retention indices),were calculated.Accord-ing to the expression of Pgp(positive and negative)and chemotherapeutical response(relief and exacerbation),patients were divid-ed into two groups between which the parameters were statistically analyzed.Results:In32patients underwent immunohisto-chemical study,Pgp positive expression was found in9cases and negative in23cases,and the statistical results showed no sig-nificance in semiquantitative parameters between positive group and negative group.In20patients receiving standard chemo-therapy with detailed clinical data,follow-up examination showed relief was achieved in half,and exacerbation occurred in the other half.Between these two groups,only in T?Ne,1.76±0.50in relief group and1.28±0.51in exacerbation group,statisti-cal significance was found.Conclusion:99m Tc -MIBI chest imaging can predict the chemosensitivity of lung cancer in chemotherapy.However,further study are required for determining the mechanism of chemosensitivity of lung cancer and the standardization of chemotherapy.
出处
《中国临床医学影像杂志》
CAS
2002年第3期179-181,225,共4页
Journal of China Clinic Medical Imaging
