摘要
在SO2 吸入慢性染毒条件下 ,小鼠骨髓嗜多染红细胞 (PCE)的微核细胞率与微核率均显著增加 ,且雌雄差异显著 .结果也表明 ,SO2 对阳性致突变剂乌拉坦诱发微核的作用有显著抑制效应 .本研究模拟SO2 空气污染 ,从整体水平直接证实了SO2 是哺乳类细胞染色体断裂剂、SO2
In the chronic inhalation experiment of sulfur dioxide(SO 2), micronuclei(MN) frequencies in the polychromatophilic erythroblasts(PCE) of mouse bone marrow and the frequencies of cells with MN were significantly increased in dose dependent manner. There was a singnificant difference between the male and the female animals. The results also showed that SO 2 inhibited urethone induced MN formation. These results furtherly confirm that SO 2 inhalation was a clastogenic and genotoxic agent to mammalian cells, and the combined effects of SO 2 and other mutagens are complex.
出处
《环境科学》
EI
CAS
CSCD
北大核心
2002年第4期123-125,共3页
Environmental Science
基金
国家自然科学基金资助项目 (30 0 70 6 4 7)
山西省自然科学基金资助项目
