摘要
本文对某硫酸厂接触二氧化硫（ＳＯ＿２）４０名工人的外周血淋巴细胞染色体畸变（ＣＡ）、姊妹染色单体互换（ＳＣＥ）、及微核（ＭＮ）进行了分析。结果表明，接触ＳＯ＿２的工人其ＣＡ、ＳＣＥ及ＭＮ均显著高于对照组。本文也分析了ＳＯ＿２在体内的代谢产物──亚硫酸氢钠对淋巴细胞的遗传毒理效应。结果指出，亚硫酸氢钠可诱发人血淋巴细胞ＣＡ，ＳＣＥ及ＭＮ，且有明确的剂量效应关系。这些研究证明，ＳＯ＿２确是人血淋巴细胞染色体断裂剂和基因毒性因子；ＳＯ＿２与癌症的关系值得进一步研究。
Frequencies of chromosomal aberrations(CA)’sister chromatid ex-chages(SCE) ,and micronuclei(MN)in blood lymphocytes from workersexposed to sulfur dioxide(SO_2 )at a sulfuric acid factory were analyzed,Itwas hown that the frequencies of CA,SCE,and MN of SO_2-exposed workerswere significantly bigher than that of controls,In this study, cytogeneticeffects of sodium bisulfite,a known metabolite from SO_2,on human lympho-cytes were also invesigated,The results show that CA,SCE and MN in thelymphocytes can be induced by sodium bisulfite in a dosedependent manner.These resuIts have confirmed that SO_2 is a clastogenic and genotoxic agent.Further study of correation between SO_2 and carcinogenesis is needed.
出处
《城市环境与城市生态》
CAS
CSSCI
CSCD
1994年第4期17-21,共5页
Urban Environment & Urban Ecology
关键词
二氧化硫
染色体畸变
淋巴细胞
遗传毒理效应
sulfur diozide,cfiromosmal aberrations,micronuclei,sister chromatid exchanges, human lymphocytes
