摘要
【目的】探讨减量雌孕激素替代疗法 (HRT)的阴道出血模式。【方法】自然绝经 1年以上妇女 30例 ,连续联合应用半量诺更宁 :1mg 17β 雌二醇 (E2 ) +0 5mg醋酸炔诺酮 (NETA) 2 4周 ,观察阴道出血时间、出血量、体质量、体质量指数(bodymassindex ,BMI)、子宫内膜厚度、用药后症状改善的时间。【结果】用药后阴道出血 10例 ,无阴道出血 2 0例。出血者多数表现为点滴状出血 ,随用药时间延长 ,出血率明显降低 ,在阴道出血的病例中 ,平均年龄 48岁 ,平均绝经年龄 44岁 ,与无阴道出血组比较有显著差异。使用半量HRT 2 4周后 ,BMI平均增加为 0 7kg/cm2 。用药 1个月后 ,严重的轰热、烦躁、多汗有缓解 ,2个月后Kupperman评分有显著差异。减量HRT对关节痛的缓解效果不明显。【结论】减量HRT能缓解低雌激素症状 ,出血率低 ,安全性高 ,临床上值得尝试用于年龄较大的绝经后老年妇女。
To determine the vaginal bleeding pattern in postmenopausal women on low dose hormone replacement therapy(HRT). 30 postmenopausal women with natural menopause at least for 1 year were treated with continuous combination of 0 5 mg norethindrone acetate and 1mg ethinyl estradiol (E 2) for 24 weeks. The period and status of breakthrough bleeding or spotting, weight, body mass index, endometrial thickness, and climacteric symptoms were recorded. During administration of HRT,10 cases appeared and 20 cases had no spotting. The rate of vaginal bleeding decreased obviously when the time of HRT increased. In women with vaginal bleeding, mean age was 48 years old and mean menopausal age was 44 years old. Significant difference was found between women with and without vaginal bleeding. Body mass index increased 0 7 kg/cm 2 after low dose HRT. Severe hot flash, irritability and night sweating relieved 4 weeks after HRT, and 12 weeks after the treatment, the Kupperman index showed significant improvement. [Conclusion] Low dose HRT is a safe and effective alternative for relieving climacteric symptoms with low rate of vaginal spotting in Chinese postmenopausal women. The younger the menopausal women, the higher rate of vaginal spotting is. Low dose of HRT is more suitable for older postmenopausal women.
出处
《中山医科大学学报》
CSCD
北大核心
2002年第4期287-290,共4页
Academic Journal of Sun Yat-sen University of Medical Sciences
基金
广东省科委自然科学基金博士启动项目 ( 1998)
关键词
雌激素替代疗法
子宫出血
绝经后期
hormone replacement therapy
uterine hemorrhage
post menopause
