摘要
目的：观察绝经后应用激素替代治疗（ＨＲＴ）妇女子宫内膜细胞的形态改变；建立子宫内膜的监测方法。方法：应用塑料管负压法，吸取绝经后妇女６０例（非ＨＲＴ组）和应用ＨＲＴ３～１８个月妇女４１例（ＨＲＴ组）的子宫内膜细胞，进行细胞病理学诊断。结果：非ＨＲＴ组内膜细胞萎缩型为５１．７％，吞噬细胞为６８．３％；随着年龄增长及绝经时间的延长，萎缩型增加。ＨＲＴ组萎缩型和吞噬细胞分别为１２．２％和１７．０％，明显低于非ＨＲＴ组（Ｐ＜０．００５）。两组细胞类型均表现不均一（即同一涂片中可见到不同时期的细胞形态）。结论：绝经后子宫内膜细胞并非呈单纯萎缩型；应用ＨＲＴ后，子宫内膜细胞形态发生显著变化；采用塑料管负压吸取子宫内膜细胞进行检查，可用于子宫内膜的监测。
Objective: To explore the possibility of endometrial cyopathologic examination as a method of monitoring endometrium during hormone replacement therapy (HRT) in postmenopausal women. Mehtods: Endometrial cells were taken via tubal aspiration in 60 normal postmenopausal women (non HRT group )and 41 with HRT for 3～18 months (HRT group). Their morphologic changes were observed and compared by cytopathologist. Results: Atrophic endometrium was found in 51.7% of the non HRT group. Its proportion increased with age and the time after menopause. Macrophages were seen in 68.3% of this group. However, in the HRT group the occurrence of atrophic type and macrophage (12.2%, 17 0% respectively) was significantly lower than that in the non HRT group ( P <0.05). Heterogeneity of endometrial cell type was shown both in non-HRT (38.3%) and HRT (65.8%) groups. Conclusions: Endometrial cells of postmenopausal women are not always atrophic in appearance. They change significantly during HRT. Endometrial cytological examination may be useful for monitoring during HRT.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1997年第7期432-435,I039,共5页
Chinese Journal of Obstetrics and Gynecology
关键词
绝经
子宫内膜
雌激素替代疗法
Menopause Endometrium Estrogen replacement therapy
